New Plastoquinones Isolated from the Brown Alga, Sargassum micracanthum

New Plastoquinones Isolated from the Brown Alga, Sargassum micracanthum

Four new plastoquinones were isolated from the methanolic extract of the brown alga, Sargassum micracanthum. Their structures were elucidated based on spectroscopic analysis and chemical conversions from 2-geranylgeranyl-6-methyl-1,4-benzohydroquinone. These plastoquinones exhibited significant anti...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Chemical & Pharmaceutical Bulletin 2005, Vol.53(9), pp.1159-1163
Hauptverfasser: Mori, Jun, Iwashima, Makoto, Wakasugi, Hiroko, Saito, Haruo, Matsunaga, Takayuki, Ogasawara, Masaru, Takahashi, Satoshi, Suzuki, Hideyo, Hayashi, Toshimitsu
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Antineoplastic Agents - pharmacology
antioxidative activity
Biphenyl Compounds - chemistry
Cell Line, Tumor
Cell Proliferation - drug effects
Chloroform
cytotoxic activity
Free Radical Scavengers - chemistry
Free Radical Scavengers - pharmacology
Hydrazines - chemistry
In Vitro Techniques
lipid peroxidation
Lipid Peroxidation - drug effects
Liver - drug effects
Liver - metabolism
Magnetic Resonance Spectroscopy
Male
Methanol
Mice
NADP - chemistry
Oxidation-Reduction
Phaeophyceae - chemistry
Picrates
plastoquinone
Quinones - chemistry
radical scavenger
Rats
Sargassum micracanthum
Solvents
Spectrometry, Mass, Electrospray Ionization
Spectrophotometry, Infrared
Spectrophotometry, Ultraviolet
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Four new plastoquinones were isolated from the methanolic extract of the brown alga, Sargassum micracanthum. Their structures were elucidated based on spectroscopic analysis and chemical conversions from 2-geranylgeranyl-6-methyl-1,4-benzohydroquinone. These plastoquinones exhibited significant antioxidant activities such as an inhibitory effect on lipid peroxidation and a radical scavenging effect on 1,1-diphenyl-2-picrylhydrazyl (DPPH). Some of the new plastoquiones showed cytotoxic activity against cancer cell line.
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.53.1159