Pattern of expression of adiponectin receptors in human adipose tissue depots and its relation to the metabolic state

Objective: To investigate whether adiponectin receptor genes ( AdipoR1 and AdipoR2 ) expression in human subcutaneous (SAT) and visceral (VAT) adipose tissue in severely obese patients with or without diabetes is related to adiponectin gene ( APM1 ) expression and in vivo metabolic parameters. Design: Cross-sectional, clinical research study. Subjects: Total RNA was extracted from SAT and VAT tissue obtained during surgery from 13 lean controls, 30 obese diabetic patients, 19 obese glucose-intolerant patients and 54 obese subjects with normal glucose tolerance. Measurements: Tissue expression of APM1 , AdipoR1 and AdipoR2 , tissue concentration of adiponectin (ApN), and metabolic variables. Results: APM1 expression was higher in SAT than VAT (1.06±0.76 vs 0.69±0.52, P