Multifunctional Magneto-Polymeric Nanohybrids for Targeted Detection and Synergistic Therapeutic Effects on Breast Cancer

Diagnosis and treatment all in one: Multifunctional magneto‐polymeric nanohybrids (MMPNs) have been synthesized using ultrasensitive MnFe2O4 nanocrystals, chemotherapeutic agents, and encapsulating amphiphilic block copolymers for targeted detection by MRI and treatment of breast cancer. See the TEM...

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Veröffentlicht in:	Angewandte Chemie (International ed.) 2007-01, Vol.46 (46), p.8836-8839
Hauptverfasser:	Yang, Jaemoon, Lee, Choong-Hwan, Ko, Hyun-Ju, Suh, Jin-Suck, Yoon, Ho-Geun, Lee, Kwangyeol, Huh, Yong-Min, Haam, Seungjoo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - therapeutic use Breast Neoplasms - drug therapy Cell Line, Tumor drug delivery Drug Delivery Systems Female Humans hybrid composites imaging agents magnetic resonance Magnetic Resonance Imaging Magnetics Mice Nanomedicine - methods Nanoparticles - therapeutic use Neoplasms, Experimental - drug therapy Polymers - therapeutic use transmission electron microscopy
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Beschreibung
Zusammenfassung:	Diagnosis and treatment all in one: Multifunctional magneto‐polymeric nanohybrids (MMPNs) have been synthesized using ultrasensitive MnFe2O4 nanocrystals, chemotherapeutic agents, and encapsulating amphiphilic block copolymers for targeted detection by MRI and treatment of breast cancer. See the TEM image (left) of an MMPN and T2‐weighted MR images (top row) and color map (bottom row) of the relaxivity R2 for NIH3T6.7 and MDA‐MB‐231 cells.
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.200703554