Hydroxyl radical generation via photoreduction of a simple pyridine N-oxide by an NADH analogue

Hydroxyl radical generation via photoreduction of a simple pyridine N-oxide by an NADH analogue

Photoreduction of pyridine N-oxide, which has a key structure of antitumor agents for hypoxic solid tumors, by 1-benzyl-1,4-dihydronicotinamide in deaerated aprotic media resulted in generation of hydroxyl radical, leading to the oxidation of salicylic acid to 2,3- and 2,5-dihydroxybenzoic acids, an...

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Veröffentlicht in:Organic & biomolecular chemistry 2005-09, Vol.3 (18), p.3263-3265
Hauptverfasser: Nakanishi, Ikuo, Nishizawa, Chiho, Ohkubo, Kei, Takeshita, Keizo, Suzuki, Kazuo T, Ozawa, Toshihiko, Hecht, Sidney M, Tanno, Masayuki, Sueyoshi, Shoko, Miyata, Naoki, Okuda, Haruhiro, Fukuzumi, Shunichi, Ikota, Nobuo, Fukuhara, Kiyoshi
Format: Artikel
Sprache:eng
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Zusammenfassung:Photoreduction of pyridine N-oxide, which has a key structure of antitumor agents for hypoxic solid tumors, by 1-benzyl-1,4-dihydronicotinamide in deaerated aprotic media resulted in generation of hydroxyl radical, leading to the oxidation of salicylic acid to 2,3- and 2,5-dihydroxybenzoic acids, and catechol.
ISSN:1477-0520
1477-0539
DOI:10.1039/b509447j