Effect of smoking on folic acid and vitamin B12 after nonsurgical periodontal intervention

Aim: The main purpose of this study was to investigate the effect of smoking on the serum levels of folic acid and vitamin B12 in smokers and nonsmokers with chronic periodontal disease after nonsurgical intervention. Material and Methods: The study base consisted of 45 current smokers and 43 nonsmokers. The clinical parameters included plaque index (PI), gingival index (GI), pocket depth (PD), and clinical attachment level (CAL). Folic acid and vitamin B12 were determined from peripheral blood samples. Clinical measurements and blood samples were collected at baseline and 1, 3, and 6 months after the intervention. Results: Mean PI was significantly greater in smokers compared with non‐smokers throughout the observation period (p