Rat brain opioid peptides-circadian rhythm is under control of melatonin

Rat brain opioid peptides-circadian rhythm is under control of melatonin

Abstract Several experiments have revealed an Endogenous Opioid System (EOS)-circadian rhythm. The brain-borne hormone, melatonin (MEL) has been shown to regulate the organism photoperiodic activity and may be implicated in the EOS-circadian rhythm. To explore this hypothesis, we studied the effect...

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Veröffentlicht in:Neuropeptides (Edinburgh) 2007-12, Vol.41 (6), p.389-397
Hauptverfasser: Miguel Asai, M.A, Lilian Mayagoitia, L.M, David García, D.G, Gilberto Matamoros-Trejo, G.M.-T, Marcela Valdés-Tovar, M.V.-T, Phillipe Leff, P.L
Format: Artikel
Sprache:eng
Schlagworte:
Advanced Basic Science
Animals
Biological and medical sciences
Brain Chemistry
Chronobiology
Circadian Rhythm
Dose-Response Relationship, Drug
Endocrinology & Metabolism
Enkephalins
Functional pinealectomy
Fundamental and applied biological sciences. Psychology
Hippocampus - chemistry
Hypothalamus - chemistry
Light
Melatonin
Melatonin - administration & dosage
Melatonin - physiology
Opioid Peptides - metabolism
Rats
Synthesis
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Vertebrates: endocrinology
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Zusammenfassung:Abstract Several experiments have revealed an Endogenous Opioid System (EOS)-circadian rhythm. The brain-borne hormone, melatonin (MEL) has been shown to regulate the organism photoperiodic activity and may be implicated in the EOS-circadian rhythm. To explore this hypothesis, we studied the effect of functional pinealectomy on the EOS-circadian rhythm by measuring the immunoreactive content of Met-Enkephalin, Leu-Enkephalin and Synenkephalin in both hypothalamus and hippocampus of the rat brain, using standard radioimmunoassay procedures. Experimental animals exposed to white fluorescent light (WFL) for 15 days (
ISSN:0143-4179
1532-2785
DOI:10.1016/j.npep.2007.09.001