The role of exercise on platelet aggregation in patients with stable coronary artery disease: exercise induces aspirin resistant platelet activation

The aim of our study was to determine the relation between exercise stress test and aspirin resistance in patients with stable coronary artery disease. Clinically aspirin resistance is defined as having thrombotic and embolic cardiovascular events despite regular aspirin therapy. We studied platelet...

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Veröffentlicht in:	Journal of thrombosis and thrombolysis 2005-08, Vol.20 (1), p.17-22
Hauptverfasser:	Pamukcu, Burak, Oflaz, Huseyin, Acar, Rezzan Deniz, Umman, Sabahattin, Koylan, Nevres, Umman, Berrin, Nisanci, Yilmaz
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aspirin - pharmacology Blood Platelets - drug effects Blood Platelets - physiology Coronary Disease - physiopathology Coronary Disease - rehabilitation Drug Resistance Exercise - physiology Female Humans Male Middle Aged Platelet Activation - drug effects Platelet Aggregation - physiology Reference Values
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Zusammenfassung:	The aim of our study was to determine the relation between exercise stress test and aspirin resistance in patients with stable coronary artery disease. Clinically aspirin resistance is defined as having thrombotic and embolic cardiovascular events despite regular aspirin therapy. We studied platelet functions of 62 patients with stable coronary artery disease and 20 subjects with normal coronary arteries by Platelet Function Analyzer (PFA-100, Dade Behring, Germany) at rest and after exertion with collagen and/or epinephrine (Col/Epi) and collagen and/or ADP cartridges. Closure time (CT)
ISSN:	0929-5305 1573-742X
DOI:	10.1007/s11239-005-2318-1