Differential effects of diabetes on CYP2E1 and CYP2B4 proteins and associated drug metabolizing enzyme activities in rabbit liver

The effects of diabetes on cytochrome P450 (CYP)-dependent drug metabolizing enzymes are yet to be clarified. The most widely used animals in these studies have been rats, and information on the effects of diabetes on rabbit liver drug metabolizing enzymes have been unavailable until now. In this st...

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Veröffentlicht in:	Archives of toxicology 2005-08, Vol.79 (8), p.427-433
Hauptverfasser:	ARINC, Emel, ARSLAN, Sevki, ADAH, Orhan
Format:	Artikel
Sprache:	eng
Schlagworte:	Alloxan Aniline Hydroxylase - metabolism Animals Aryl Hydrocarbon Hydroxylases - metabolism Biological and medical sciences Cytochrome P-450 CYP2E1 - metabolism Cytochrome P-450 Enzyme System - metabolism Cytochrome P450 Family 2 Diabetes Diabetes Mellitus, Experimental - enzymology Disease Models, Animal Enzyme Induction Male Medical sciences Microsomes, Liver - drug effects Microsomes, Liver - enzymology Oxidoreductases, N-Demethylating - metabolism Rabbits Rodents Species Specificity Toxicology
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Zusammenfassung:	The effects of diabetes on cytochrome P450 (CYP)-dependent drug metabolizing enzymes are yet to be clarified. The most widely used animals in these studies have been rats, and information on the effects of diabetes on rabbit liver drug metabolizing enzymes have been unavailable until now. In this study, for the first time, a significant induction of liver CYP2E1 is demonstrated via immunoblot analysis in alloxan-induced rabbits. The CYP2E1 content of diabetic microsomes was highly correlated with the activities of liver aniline 4-hydroxylase (r=0.82, p
ISSN:	0340-5761 1432-0738
DOI:	10.1007/s00204-005-0654-8