Nanoscale microcavity sensor for single particle detection

Recently we demonstrated a biosensor based on a two-dimensional photonic crystal microcavity for detection of proteins. We present a theoretical and experimental study of a modified structure for single particle detection. With an active sensing volume of approximately 0.15 microm(3), the device is...

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Veröffentlicht in:	Optics letters 2007-11, Vol.32 (22), p.3284-3286
Hauptverfasser:	LEE, Mindy R, FAUCHET, Philippe M
Format:	Artikel
Sprache:	eng
Schlagworte:	Biosensing Techniques Computer Simulation Crystallization Electronics Equipment Design Exact sciences and technology Fundamental areas of phenomenology (including applications) General equipment and techniques Instruments, apparatus, components and techniques common to several branches of physics and astronomy Lasers Latex Microscopy, Electron, Scanning Models, Theoretical Nanoparticles - chemistry Nanotechnology - instrumentation Nanotechnology - methods Optical materials Optics Optics and Photonics Photonic bandgap materials Photons Physics Proteins - chemistry Sensors (chemical, optical, electrical, movement, gas, etc.) remote sensing Spectrum Analysis, Raman - instrumentation Spectrum Analysis, Raman - methods
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Beschreibung
Zusammenfassung:	Recently we demonstrated a biosensor based on a two-dimensional photonic crystal microcavity for detection of proteins. We present a theoretical and experimental study of a modified structure for single particle detection. With an active sensing volume of approximately 0.15 microm(3), the device is capable of detecting approximately 1 fg of matter. Its performance is tested with latex spheres with sizes that fall in the size range of a variety of viruses.
ISSN:	0146-9592 1539-4794
DOI:	10.1364/OL.32.003284