Overview of boosted protease inhibitors in treatment-experienced HIV-infected patients

Antiretroviral drug combinations that include two nucleoside reverse transcriptase inhibitors and a protease inhibitor (PI) can suppress HIV replication to undetectable levels, improving the prognosis of HIV-infected individuals. The aim of therapy is complete virological suppression, with a current...

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Veröffentlicht in:	Journal of antimicrobial chemotherapy 2007-12, Vol.60 (6), p.1195-1205
1. Verfasser:	Youle, Mike
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics. Antiinfectious agents. Antiparasitic agents Antiretroviral drugs antiretroviral therapy antiviral Biological and medical sciences Biomedical research Drug Resistance, Viral - genetics Drug Therapy, Combination Europe HIV HIV Infections - drug therapy HIV Infections - virology HIV Protease - drug effects HIV Protease - genetics HIV Protease Inhibitors - administration & dosage HIV Protease Inhibitors - classification HIV Protease Inhibitors - therapeutic use HIV-1 - drug effects HIV-1 - enzymology HIV-1 - genetics Human immunodeficiency virus Human immunodeficiency virus 1 Human viral diseases Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Infectious diseases Medical prognosis Medical sciences Microbiology Pharmacology Pharmacology. Drug treatments PIs Protease inhibitors Randomized Controlled Trials as Topic Ritonavir - administration & dosage Ritonavir - therapeutic use Treatment Outcome United States Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids
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Beschreibung
Zusammenfassung:	Antiretroviral drug combinations that include two nucleoside reverse transcriptase inhibitors and a protease inhibitor (PI) can suppress HIV replication to undetectable levels, improving the prognosis of HIV-infected individuals. The aim of therapy is complete virological suppression, with a current goal of
ISSN:	0305-7453 1460-2091
DOI:	10.1093/jac/dkm364