Imaging of Photodynamically Generated Singlet Oxygen Luminescence In Vivo

Imaging of Photodynamically Generated Singlet Oxygen Luminescence In Vivo

We describe a novel scanning-laser system for imaging type-II photodynamically generated singlet oxygen (1O2[1Δg]) luminescence and demonstrate it in vivo in an intradermal tumor model in mice. We verify the strong oxygen-dependence of the signal and show that the images are near the practical resol...

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Veröffentlicht in:Photochemistry and photobiology 2005-07, Vol.81 (4), p.941-943
Hauptverfasser: Niedre, Mark J., Patterson, Michael S., Giles, Anoja, Wilson, Brian C.
Format: Artikel
Sprache:eng
Schlagworte:
Light
Luminescent Measurements
Research s
Singlet Oxygen
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Zusammenfassung:We describe a novel scanning-laser system for imaging type-II photodynamically generated singlet oxygen (1O2[1Δg]) luminescence and demonstrate it in vivo in an intradermal tumor model in mice. We verify the strong oxygen-dependence of the signal and show that the images are near the practical resolution limit.
ISSN:0031-8655
1751-1097
DOI:10.1562/2005-03-15-TSN-462R.1