Hypoglycemic effect of Malmea depressa root on streptozotocin diabetic rats
The hypoglycemic effects of water, ethanolic and butanolic extracts prepared from the root of Malmea depressa (Baill) R.E. Fries. (Annonaceae) were studied in diabetic rats (streptozotocin induced). Oral application of water extracts at doses of 40 and 80 mg/kg, ethanolic (112 mg/kg) and butanolic (...
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| Veröffentlicht in: | Journal of ethnopharmacology 2005-09, Vol.100 (3), p.319-322 |
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| creator | Andrade-Cetto, Adolfo Martínez-Zurita, Eddy Wiedenfeld, Helmut |
| description | The hypoglycemic effects of water, ethanolic and butanolic extracts prepared from the root of
Malmea depressa (Baill) R.E. Fries. (Annonaceae) were studied in diabetic rats (streptozotocin induced). Oral application of water extracts at doses of 40 and 80
mg/kg, ethanolic (112
mg/kg) and butanolic (80
mg/kg) extracts significantly lowered the plasma glucose levels in diabetic rats within three hours. Glibenclamide and metformin were used as references and showed similar hypoglycemic effects like the extracts. The three extracts have a similar chemical composition (HPLC analysis). |
| doi_str_mv | 10.1016/j.jep.2005.03.021 |
| format | Article |
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Malmea depressa (Baill) R.E. Fries. (Annonaceae) were studied in diabetic rats (streptozotocin induced). Oral application of water extracts at doses of 40 and 80
mg/kg, ethanolic (112
mg/kg) and butanolic (80
mg/kg) extracts significantly lowered the plasma glucose levels in diabetic rats within three hours. Glibenclamide and metformin were used as references and showed similar hypoglycemic effects like the extracts. The three extracts have a similar chemical composition (HPLC analysis).</description><identifier>ISSN: 0378-8741</identifier><identifier>EISSN: 1872-7573</identifier><identifier>DOI: 10.1016/j.jep.2005.03.021</identifier><identifier>PMID: 15990260</identifier><identifier>CODEN: JOETD7</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Animals ; Annonaceae ; Annonaceae - chemistry ; bioassays ; Biological and medical sciences ; Blood Glucose - metabolism ; chemical constituents of plants ; Chromatography, High Pressure Liquid ; diabetes mellitus ; Diabetes Mellitus, Experimental - blood ; Diabetes Mellitus, Experimental - drug therapy ; Ethanol ; ethnobotany ; General pharmacology ; Glyburide - pharmacology ; herbal medicines ; hypoglycemic agents ; Hypoglycemic Agents - pharmacology ; Hypoglycemic effect ; Male ; Malmea depressa ; Medical sciences ; medicinal plants ; medicinal properties ; Medicine, Traditional ; Metformin - pharmacology ; Mexican plants ; Mexico ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; plant extracts ; Plant Extracts - chemistry ; Plant Extracts - pharmacology ; Plant Roots - chemistry ; Rats ; Rats, Wistar ; roots ; Solvents ; Streptozotocin-induced diabetic rats ; traditional medicine ; Water</subject><ispartof>Journal of ethnopharmacology, 2005-09, Vol.100 (3), p.319-322</ispartof><rights>2005 Elsevier Ireland Ltd</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c320t-b483009e3ee7a0f1e0657b3fea27ebec35b20c962193830eaec4566d62bd9be23</citedby><cites>FETCH-LOGICAL-c320t-b483009e3ee7a0f1e0657b3fea27ebec35b20c962193830eaec4566d62bd9be23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jep.2005.03.021$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17067573$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15990260$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Andrade-Cetto, Adolfo</creatorcontrib><creatorcontrib>Martínez-Zurita, Eddy</creatorcontrib><creatorcontrib>Wiedenfeld, Helmut</creatorcontrib><title>Hypoglycemic effect of Malmea depressa root on streptozotocin diabetic rats</title><title>Journal of ethnopharmacology</title><addtitle>J Ethnopharmacol</addtitle><description>The hypoglycemic effects of water, ethanolic and butanolic extracts prepared from the root of
Malmea depressa (Baill) R.E. Fries. (Annonaceae) were studied in diabetic rats (streptozotocin induced). Oral application of water extracts at doses of 40 and 80
mg/kg, ethanolic (112
mg/kg) and butanolic (80
mg/kg) extracts significantly lowered the plasma glucose levels in diabetic rats within three hours. Glibenclamide and metformin were used as references and showed similar hypoglycemic effects like the extracts. The three extracts have a similar chemical composition (HPLC analysis).</description><subject>Animals</subject><subject>Annonaceae</subject><subject>Annonaceae - chemistry</subject><subject>bioassays</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - metabolism</subject><subject>chemical constituents of plants</subject><subject>Chromatography, High Pressure Liquid</subject><subject>diabetes mellitus</subject><subject>Diabetes Mellitus, Experimental - blood</subject><subject>Diabetes Mellitus, Experimental - drug therapy</subject><subject>Ethanol</subject><subject>ethnobotany</subject><subject>General pharmacology</subject><subject>Glyburide - pharmacology</subject><subject>herbal medicines</subject><subject>hypoglycemic agents</subject><subject>Hypoglycemic Agents - pharmacology</subject><subject>Hypoglycemic effect</subject><subject>Male</subject><subject>Malmea depressa</subject><subject>Medical sciences</subject><subject>medicinal plants</subject><subject>medicinal properties</subject><subject>Medicine, Traditional</subject><subject>Metformin - pharmacology</subject><subject>Mexican plants</subject><subject>Mexico</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>plant extracts</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Roots - chemistry</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>roots</subject><subject>Solvents</subject><subject>Streptozotocin-induced diabetic rats</subject><subject>traditional medicine</subject><subject>Water</subject><issn>0378-8741</issn><issn>1872-7573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90UFr2zAUwHExOtY06wfYZfNlvdl9kmzJpqcStqa0Y4e1ZyHLT0XBtjzJGaSffgoO9NaTQPyeEP9HyBcKBQUqrnfFDqeCAVQF8AIY_UBWtJYsl5XkZ2QFXNZ5LUt6Ti5i3AGApCV8Iue0ahpgAlbkYXuY_Et_MDg4k6G1aObM2-yX7gfUWYdTwBh1FrxP92MW54DT7F_97I0bs87pFuc0GfQcP5OPVvcRL0_nmjz__PG02eaPv-_uN7ePueEM5rwtaw7QIEeUGixFEJVsuUXNJLZoeNUyMI1gtOFJokZTVkJ0grVd0yLja3K1vDsF_3ePcVaDiwb7Xo_o91GJumJ1yaoE6QJN8DEGtGoKbtDhoCioY0G1U6mgOhZUwFUqmGa-nh7ftwN2bxOnZAl8PwEdje5t0KNx8c1JEMf8yX1bnNVe6ZeQzPMfBpQDBZ62VCZxswhMsf45DCoah6PBzoW0BtV5985H_wMGCJed</recordid><startdate>20050914</startdate><enddate>20050914</enddate><creator>Andrade-Cetto, Adolfo</creator><creator>Martínez-Zurita, Eddy</creator><creator>Wiedenfeld, Helmut</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050914</creationdate><title>Hypoglycemic effect of Malmea depressa root on streptozotocin diabetic rats</title><author>Andrade-Cetto, Adolfo ; Martínez-Zurita, Eddy ; Wiedenfeld, Helmut</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c320t-b483009e3ee7a0f1e0657b3fea27ebec35b20c962193830eaec4566d62bd9be23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animals</topic><topic>Annonaceae</topic><topic>Annonaceae - chemistry</topic><topic>bioassays</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - metabolism</topic><topic>chemical constituents of plants</topic><topic>Chromatography, High Pressure Liquid</topic><topic>diabetes mellitus</topic><topic>Diabetes Mellitus, Experimental - blood</topic><topic>Diabetes Mellitus, Experimental - drug therapy</topic><topic>Ethanol</topic><topic>ethnobotany</topic><topic>General pharmacology</topic><topic>Glyburide - pharmacology</topic><topic>herbal medicines</topic><topic>hypoglycemic agents</topic><topic>Hypoglycemic Agents - pharmacology</topic><topic>Hypoglycemic effect</topic><topic>Male</topic><topic>Malmea depressa</topic><topic>Medical sciences</topic><topic>medicinal plants</topic><topic>medicinal properties</topic><topic>Medicine, Traditional</topic><topic>Metformin - pharmacology</topic><topic>Mexican plants</topic><topic>Mexico</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>plant extracts</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Roots - chemistry</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>roots</topic><topic>Solvents</topic><topic>Streptozotocin-induced diabetic rats</topic><topic>traditional medicine</topic><topic>Water</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Andrade-Cetto, Adolfo</creatorcontrib><creatorcontrib>Martínez-Zurita, Eddy</creatorcontrib><creatorcontrib>Wiedenfeld, Helmut</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of ethnopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Andrade-Cetto, Adolfo</au><au>Martínez-Zurita, Eddy</au><au>Wiedenfeld, Helmut</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hypoglycemic effect of Malmea depressa root on streptozotocin diabetic rats</atitle><jtitle>Journal of ethnopharmacology</jtitle><addtitle>J Ethnopharmacol</addtitle><date>2005-09-14</date><risdate>2005</risdate><volume>100</volume><issue>3</issue><spage>319</spage><epage>322</epage><pages>319-322</pages><issn>0378-8741</issn><eissn>1872-7573</eissn><coden>JOETD7</coden><abstract>The hypoglycemic effects of water, ethanolic and butanolic extracts prepared from the root of
Malmea depressa (Baill) R.E. Fries. (Annonaceae) were studied in diabetic rats (streptozotocin induced). Oral application of water extracts at doses of 40 and 80
mg/kg, ethanolic (112
mg/kg) and butanolic (80
mg/kg) extracts significantly lowered the plasma glucose levels in diabetic rats within three hours. Glibenclamide and metformin were used as references and showed similar hypoglycemic effects like the extracts. The three extracts have a similar chemical composition (HPLC analysis).</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>15990260</pmid><doi>10.1016/j.jep.2005.03.021</doi><tpages>4</tpages></addata></record> |
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| subjects | Animals Annonaceae Annonaceae - chemistry bioassays Biological and medical sciences Blood Glucose - metabolism chemical constituents of plants Chromatography, High Pressure Liquid diabetes mellitus Diabetes Mellitus, Experimental - blood Diabetes Mellitus, Experimental - drug therapy Ethanol ethnobotany General pharmacology Glyburide - pharmacology herbal medicines hypoglycemic agents Hypoglycemic Agents - pharmacology Hypoglycemic effect Male Malmea depressa Medical sciences medicinal plants medicinal properties Medicine, Traditional Metformin - pharmacology Mexican plants Mexico Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments plant extracts Plant Extracts - chemistry Plant Extracts - pharmacology Plant Roots - chemistry Rats Rats, Wistar roots Solvents Streptozotocin-induced diabetic rats traditional medicine Water |
| title | Hypoglycemic effect of Malmea depressa root on streptozotocin diabetic rats |
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