Hypoglycemic effect of Malmea depressa root on streptozotocin diabetic rats

The hypoglycemic effects of water, ethanolic and butanolic extracts prepared from the root of Malmea depressa (Baill) R.E. Fries. (Annonaceae) were studied in diabetic rats (streptozotocin induced). Oral application of water extracts at doses of 40 and 80 mg/kg, ethanolic (112 mg/kg) and butanolic (...

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Veröffentlicht in:	Journal of ethnopharmacology 2005-09, Vol.100 (3), p.319-322
Hauptverfasser:	Andrade-Cetto, Adolfo, Martínez-Zurita, Eddy, Wiedenfeld, Helmut
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Annonaceae Annonaceae - chemistry bioassays Biological and medical sciences Blood Glucose - metabolism chemical constituents of plants Chromatography, High Pressure Liquid diabetes mellitus Diabetes Mellitus, Experimental - blood Diabetes Mellitus, Experimental - drug therapy Ethanol ethnobotany General pharmacology Glyburide - pharmacology herbal medicines hypoglycemic agents Hypoglycemic Agents - pharmacology Hypoglycemic effect Male Malmea depressa Medical sciences medicinal plants medicinal properties Medicine, Traditional Metformin - pharmacology Mexican plants Mexico Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments plant extracts Plant Extracts - chemistry Plant Extracts - pharmacology Plant Roots - chemistry Rats Rats, Wistar roots Solvents Streptozotocin-induced diabetic rats traditional medicine Water
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Zusammenfassung:	The hypoglycemic effects of water, ethanolic and butanolic extracts prepared from the root of Malmea depressa (Baill) R.E. Fries. (Annonaceae) were studied in diabetic rats (streptozotocin induced). Oral application of water extracts at doses of 40 and 80 mg/kg, ethanolic (112 mg/kg) and butanolic (80 mg/kg) extracts significantly lowered the plasma glucose levels in diabetic rats within three hours. Glibenclamide and metformin were used as references and showed similar hypoglycemic effects like the extracts. The three extracts have a similar chemical composition (HPLC analysis).
ISSN:	0378-8741 1872-7573
DOI:	10.1016/j.jep.2005.03.021