p-Aminoacetophenonic acids produced by a mangrove endophyte: Streptomyces griseus subsp

Three new p-aminoacetophenonic acids, named 7-(4-aminophenyl)-2,4-dimethyl-7-oxo-hept-5-enoic acid (1), 9-(4-aminophenyl)-7-hydroxy-2,4,6-trimethyl-9-oxo-non-2-enoic acid (2), and 12-(4-aminophenyl)-10-hydroxy-6-(1-hydroxyethyl)-7,9-dimethyl-12-oxo-dodeca-2,4-dienoic acid (3), were isolated from an...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2005-08, Vol.68 (8), p.1198-1200
Hauptverfasser:	Guan, S.H, Sattler, I, Lin, W.H, Guo, D.A, Grabley, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetophenones - chemistry Acetophenones - isolation & purification Acetophenones - pharmacology Bacteria - drug effects Bacteriology Biological and medical sciences chemical structure China endophytes Fundamental and applied biological sciences. Psychology Fungi - drug effects HeLa Cells Humans Hydroxysteroid Dehydrogenases - drug effects Kandelia candel ketones Macrophages - drug effects Mass Spectrometry Microbiology Molecular Structure Morphology, structure, chemical composition Nuclear Magnetic Resonance, Biomolecular p-aminoacetophenonic acid Rhizophoraceae spectral analysis Stereoisomerism Streptomyces griseus Streptomyces griseus - chemistry Tumor Cells, Cultured
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Zusammenfassung:	Three new p-aminoacetophenonic acids, named 7-(4-aminophenyl)-2,4-dimethyl-7-oxo-hept-5-enoic acid (1), 9-(4-aminophenyl)-7-hydroxy-2,4,6-trimethyl-9-oxo-non-2-enoic acid (2), and 12-(4-aminophenyl)-10-hydroxy-6-(1-hydroxyethyl)-7,9-dimethyl-12-oxo-dodeca-2,4-dienoic acid (3), were isolated from an endophyte of the mangrove plant Kandelia candel. The structures of 1-3 were elucidated using spectroscopic analyses, primarily NMR and MS.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np0500777