Evolution of Individual Renal Function in Children with Unilateral Complex Renal Duplication
To assess the evolution of individual renal function during the maturation process in terms of single kidney glomerular filtration rate (SKGFR) and split function in children with unilateral complex renal duplication. We retrospectively reviewed the records of 44 children with unilateral complex dup...
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| Veröffentlicht in: | The Journal of pediatrics 2005-08, Vol.147 (2), p.208-212 |
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| creator | Ismaili, Khalid Hall, Michelle Ham, Hamphrey Piepsz, Amy |
| description | To assess the evolution of individual renal function during the maturation process in terms of single kidney glomerular filtration rate (SKGFR) and split function in children with unilateral complex renal duplication.
We retrospectively reviewed the records of 44 children with unilateral complex duplex kidney. All affected kidneys had a poor or nonfunctioning dysplastic moiety, 28 in the upper pole and 16 in the lower pole. At least 2 radioisotopic examinations, including a 99mTc-mercaptoacetyltriglycine (99mTc-MAG3) renogram and a plasma clearance of 51Cr-ethylenediaminetetraacetic acid (Cr-51 EDTA), were performed in all children, the first one performed at a median age of 3 months (range 2 to 15 months) and the last one at 24 months (range 12 to 120 months). They allowed a precise estimation of split renal function, overall glomerular filtration rate (GFR), and SKGFR.
Mean overall kidney GFR increased significantly between the two measurements from 63 ± 12.7 mL/minute/1.73m
2 to 95 ± 21 mL/minute/1.73m
2 (
P |
| doi_str_mv | 10.1016/j.jpeds.2005.03.048 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68526460</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0022347605002799</els_id><sourcerecordid>68526460</sourcerecordid><originalsourceid>FETCH-LOGICAL-c387t-d6cb78b7bc83f94bc64b6f234303cae19b4703c9ce8ae2ac912bf8638188a3853</originalsourceid><addsrcrecordid>eNp9kMFq3DAQhkVISbZJniAQfEludkeSV5YPOYRNtg0ECqW5BYQsj4kWrexI9rZ5-2qzhtx6mRmY7x-Gj5BLCgUFKr5tis2AbSwYwLIAXkApj8iCQl3lQnJ-TBYAjOW8rMQp-RrjBgDqEuCEnFJBmYAlXZCXh13vptH2Puu77NG3dmfbSbvsF_pU15M3H0vrs9WrdW1An_2x42v27K3TI4YErfrt4PDvHLmfBmeN3qfOyZdOu4gXcz8jz-uH36sf-dPP74-ru6fccFmNeStMU8mmaozkXV02RpSN6BgvOXCjkdZNWaWpNig1Mm1qyppOCi6plJrLJT8jN4e7Q-jfJoyj2tpo0DntsZ-iEnLJRCkggfwAmtDHGLBTQ7BbHd4VBbWXqjbqQ6raS1XAVZKaUlfz-anZYvuZmS0m4HoGdDTadUF7Y-MnV1FeCSYSd3vgMMnYWQwqGoveYGsDmlG1vf3vI_8AbMiWzQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>68526460</pqid></control><display><type>article</type><title>Evolution of Individual Renal Function in Children with Unilateral Complex Renal Duplication</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Ismaili, Khalid ; Hall, Michelle ; Ham, Hamphrey ; Piepsz, Amy</creator><creatorcontrib>Ismaili, Khalid ; Hall, Michelle ; Ham, Hamphrey ; Piepsz, Amy</creatorcontrib><description>To assess the evolution of individual renal function during the maturation process in terms of single kidney glomerular filtration rate (SKGFR) and split function in children with unilateral complex renal duplication.
We retrospectively reviewed the records of 44 children with unilateral complex duplex kidney. All affected kidneys had a poor or nonfunctioning dysplastic moiety, 28 in the upper pole and 16 in the lower pole. At least 2 radioisotopic examinations, including a 99mTc-mercaptoacetyltriglycine (99mTc-MAG3) renogram and a plasma clearance of 51Cr-ethylenediaminetetraacetic acid (Cr-51 EDTA), were performed in all children, the first one performed at a median age of 3 months (range 2 to 15 months) and the last one at 24 months (range 12 to 120 months). They allowed a precise estimation of split renal function, overall glomerular filtration rate (GFR), and SKGFR.
Mean overall kidney GFR increased significantly between the two measurements from 63 ± 12.7 mL/minute/1.73m
2 to 95 ± 21 mL/minute/1.73m
2 (
P <.0001). SKGFR of the duplex side similarly increased from 26 ± 7.7 mL/minute/1.73m
2 to 38 ± 12.6 mL/minute/1.73m
2 (
P <.0001). In terms of split function, the affected kidney had a remarkable stable function between the two measurements, 40% ± 8.6 and 39% ± 8.3 (
P
=
.94), respectively. However, cases with the lowest initial split function (<30%) had the lowest initial SKGFR and the worst further evolution.
In children with unilateral complex renal duplication, we found on the affected side a significant increase of SKGFR because of renal maturation, whereas mean split function remained stable during follow-up.</description><identifier>ISSN: 0022-3476</identifier><identifier>EISSN: 1097-6833</identifier><identifier>DOI: 10.1016/j.jpeds.2005.03.048</identifier><identifier>PMID: 16126051</identifier><identifier>CODEN: JOPDAB</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Biological and medical sciences ; Edetic Acid - blood ; Edetic Acid - pharmacokinetics ; Female ; General aspects ; Glomerular Filtration Rate ; Humans ; Infant ; Kidney - abnormalities ; Kidney - diagnostic imaging ; Kidney - physiopathology ; Male ; Medical Records ; Medical sciences ; Metabolic Clearance Rate ; Radionuclide Imaging ; Registries ; Retrospective Studies</subject><ispartof>The Journal of pediatrics, 2005-08, Vol.147 (2), p.208-212</ispartof><rights>2005 Elsevier Inc.</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c387t-d6cb78b7bc83f94bc64b6f234303cae19b4703c9ce8ae2ac912bf8638188a3853</citedby><cites>FETCH-LOGICAL-c387t-d6cb78b7bc83f94bc64b6f234303cae19b4703c9ce8ae2ac912bf8638188a3853</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0022347605002799$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17137626$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16126051$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ismaili, Khalid</creatorcontrib><creatorcontrib>Hall, Michelle</creatorcontrib><creatorcontrib>Ham, Hamphrey</creatorcontrib><creatorcontrib>Piepsz, Amy</creatorcontrib><title>Evolution of Individual Renal Function in Children with Unilateral Complex Renal Duplication</title><title>The Journal of pediatrics</title><addtitle>J Pediatr</addtitle><description>To assess the evolution of individual renal function during the maturation process in terms of single kidney glomerular filtration rate (SKGFR) and split function in children with unilateral complex renal duplication.
We retrospectively reviewed the records of 44 children with unilateral complex duplex kidney. All affected kidneys had a poor or nonfunctioning dysplastic moiety, 28 in the upper pole and 16 in the lower pole. At least 2 radioisotopic examinations, including a 99mTc-mercaptoacetyltriglycine (99mTc-MAG3) renogram and a plasma clearance of 51Cr-ethylenediaminetetraacetic acid (Cr-51 EDTA), were performed in all children, the first one performed at a median age of 3 months (range 2 to 15 months) and the last one at 24 months (range 12 to 120 months). They allowed a precise estimation of split renal function, overall glomerular filtration rate (GFR), and SKGFR.
Mean overall kidney GFR increased significantly between the two measurements from 63 ± 12.7 mL/minute/1.73m
2 to 95 ± 21 mL/minute/1.73m
2 (
P <.0001). SKGFR of the duplex side similarly increased from 26 ± 7.7 mL/minute/1.73m
2 to 38 ± 12.6 mL/minute/1.73m
2 (
P <.0001). In terms of split function, the affected kidney had a remarkable stable function between the two measurements, 40% ± 8.6 and 39% ± 8.3 (
P
=
.94), respectively. However, cases with the lowest initial split function (<30%) had the lowest initial SKGFR and the worst further evolution.
In children with unilateral complex renal duplication, we found on the affected side a significant increase of SKGFR because of renal maturation, whereas mean split function remained stable during follow-up.</description><subject>Biological and medical sciences</subject><subject>Edetic Acid - blood</subject><subject>Edetic Acid - pharmacokinetics</subject><subject>Female</subject><subject>General aspects</subject><subject>Glomerular Filtration Rate</subject><subject>Humans</subject><subject>Infant</subject><subject>Kidney - abnormalities</subject><subject>Kidney - diagnostic imaging</subject><subject>Kidney - physiopathology</subject><subject>Male</subject><subject>Medical Records</subject><subject>Medical sciences</subject><subject>Metabolic Clearance Rate</subject><subject>Radionuclide Imaging</subject><subject>Registries</subject><subject>Retrospective Studies</subject><issn>0022-3476</issn><issn>1097-6833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFq3DAQhkVISbZJniAQfEludkeSV5YPOYRNtg0ECqW5BYQsj4kWrexI9rZ5-2qzhtx6mRmY7x-Gj5BLCgUFKr5tis2AbSwYwLIAXkApj8iCQl3lQnJ-TBYAjOW8rMQp-RrjBgDqEuCEnFJBmYAlXZCXh13vptH2Puu77NG3dmfbSbvsF_pU15M3H0vrs9WrdW1An_2x42v27K3TI4YErfrt4PDvHLmfBmeN3qfOyZdOu4gXcz8jz-uH36sf-dPP74-ru6fccFmNeStMU8mmaozkXV02RpSN6BgvOXCjkdZNWaWpNig1Mm1qyppOCi6plJrLJT8jN4e7Q-jfJoyj2tpo0DntsZ-iEnLJRCkggfwAmtDHGLBTQ7BbHd4VBbWXqjbqQ6raS1XAVZKaUlfz-anZYvuZmS0m4HoGdDTadUF7Y-MnV1FeCSYSd3vgMMnYWQwqGoveYGsDmlG1vf3vI_8AbMiWzQ</recordid><startdate>20050801</startdate><enddate>20050801</enddate><creator>Ismaili, Khalid</creator><creator>Hall, Michelle</creator><creator>Ham, Hamphrey</creator><creator>Piepsz, Amy</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050801</creationdate><title>Evolution of Individual Renal Function in Children with Unilateral Complex Renal Duplication</title><author>Ismaili, Khalid ; Hall, Michelle ; Ham, Hamphrey ; Piepsz, Amy</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c387t-d6cb78b7bc83f94bc64b6f234303cae19b4703c9ce8ae2ac912bf8638188a3853</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Biological and medical sciences</topic><topic>Edetic Acid - blood</topic><topic>Edetic Acid - pharmacokinetics</topic><topic>Female</topic><topic>General aspects</topic><topic>Glomerular Filtration Rate</topic><topic>Humans</topic><topic>Infant</topic><topic>Kidney - abnormalities</topic><topic>Kidney - diagnostic imaging</topic><topic>Kidney - physiopathology</topic><topic>Male</topic><topic>Medical Records</topic><topic>Medical sciences</topic><topic>Metabolic Clearance Rate</topic><topic>Radionuclide Imaging</topic><topic>Registries</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ismaili, Khalid</creatorcontrib><creatorcontrib>Hall, Michelle</creatorcontrib><creatorcontrib>Ham, Hamphrey</creatorcontrib><creatorcontrib>Piepsz, Amy</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ismaili, Khalid</au><au>Hall, Michelle</au><au>Ham, Hamphrey</au><au>Piepsz, Amy</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evolution of Individual Renal Function in Children with Unilateral Complex Renal Duplication</atitle><jtitle>The Journal of pediatrics</jtitle><addtitle>J Pediatr</addtitle><date>2005-08-01</date><risdate>2005</risdate><volume>147</volume><issue>2</issue><spage>208</spage><epage>212</epage><pages>208-212</pages><issn>0022-3476</issn><eissn>1097-6833</eissn><coden>JOPDAB</coden><abstract>To assess the evolution of individual renal function during the maturation process in terms of single kidney glomerular filtration rate (SKGFR) and split function in children with unilateral complex renal duplication.
We retrospectively reviewed the records of 44 children with unilateral complex duplex kidney. All affected kidneys had a poor or nonfunctioning dysplastic moiety, 28 in the upper pole and 16 in the lower pole. At least 2 radioisotopic examinations, including a 99mTc-mercaptoacetyltriglycine (99mTc-MAG3) renogram and a plasma clearance of 51Cr-ethylenediaminetetraacetic acid (Cr-51 EDTA), were performed in all children, the first one performed at a median age of 3 months (range 2 to 15 months) and the last one at 24 months (range 12 to 120 months). They allowed a precise estimation of split renal function, overall glomerular filtration rate (GFR), and SKGFR.
Mean overall kidney GFR increased significantly between the two measurements from 63 ± 12.7 mL/minute/1.73m
2 to 95 ± 21 mL/minute/1.73m
2 (
P <.0001). SKGFR of the duplex side similarly increased from 26 ± 7.7 mL/minute/1.73m
2 to 38 ± 12.6 mL/minute/1.73m
2 (
P <.0001). In terms of split function, the affected kidney had a remarkable stable function between the two measurements, 40% ± 8.6 and 39% ± 8.3 (
P
=
.94), respectively. However, cases with the lowest initial split function (<30%) had the lowest initial SKGFR and the worst further evolution.
In children with unilateral complex renal duplication, we found on the affected side a significant increase of SKGFR because of renal maturation, whereas mean split function remained stable during follow-up.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>16126051</pmid><doi>10.1016/j.jpeds.2005.03.048</doi><tpages>5</tpages></addata></record> |
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| subjects | Biological and medical sciences Edetic Acid - blood Edetic Acid - pharmacokinetics Female General aspects Glomerular Filtration Rate Humans Infant Kidney - abnormalities Kidney - diagnostic imaging Kidney - physiopathology Male Medical Records Medical sciences Metabolic Clearance Rate Radionuclide Imaging Registries Retrospective Studies |
| title | Evolution of Individual Renal Function in Children with Unilateral Complex Renal Duplication |
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