Evolution of Individual Renal Function in Children with Unilateral Complex Renal Duplication

To assess the evolution of individual renal function during the maturation process in terms of single kidney glomerular filtration rate (SKGFR) and split function in children with unilateral complex renal duplication. We retrospectively reviewed the records of 44 children with unilateral complex duplex kidney. All affected kidneys had a poor or nonfunctioning dysplastic moiety, 28 in the upper pole and 16 in the lower pole. At least 2 radioisotopic examinations, including a 99mTc-mercaptoacetyltriglycine (99mTc-MAG3) renogram and a plasma clearance of 51Cr-ethylenediaminetetraacetic acid (Cr-51 EDTA), were performed in all children, the first one performed at a median age of 3 months (range 2 to 15 months) and the last one at 24 months (range 12 to 120 months). They allowed a precise estimation of split renal function, overall glomerular filtration rate (GFR), and SKGFR. Mean overall kidney GFR increased significantly between the two measurements from 63 ± 12.7 mL/minute/1.73m 2 to 95 ± 21 mL/minute/1.73m 2 ( P