In Vivo Optical Imaging of Amyloid Aggregates in Brain: Design of Fluorescent Markers

Routine diagnostics and studies of Alzheimer's disease might benefit form the noninvasive optical imaging of amyloid‐β plaques in the brain. A rational design strategy for in vivo amyloid‐imaging agents that enter the brain and selectively stain amyloid plaques is presented (see picture), and p...

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Veröffentlicht in:	Angewandte Chemie International Edition 2005-08, Vol.44 (34), p.5452-5456
Hauptverfasser:	Nesterov, Evgueni E., Skoch, Jesse, Hyman, Bradley T., Klunk, William E., Bacskai, Brian J., Swager, Timothy M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - diagnosis Alzheimer's disease Amyloid - chemistry Amyloid - metabolism Animals Brain - metabolism Diagnostic Imaging - methods dyes/pigments Fluorescent Dyes - chemical synthesis Fluorescent Dyes - chemistry Fluorescent Dyes - pharmacokinetics fluorescent probes imaging agents Mice Molecular Structure Nitriles - chemical synthesis Nitriles - chemistry Nitriles - pharmacokinetics Spectrometry, Fluorescence synthesis design Thiophenes - chemical synthesis Thiophenes - chemistry Thiophenes - pharmacokinetics
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Beschreibung
Zusammenfassung:	Routine diagnostics and studies of Alzheimer's disease might benefit form the noninvasive optical imaging of amyloid‐β plaques in the brain. A rational design strategy for in vivo amyloid‐imaging agents that enter the brain and selectively stain amyloid plaques is presented (see picture), and properties of a promising lead biomarker candidate are reported.
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.200500845