Sex-specific association of the human PTPN22 1858T-allele with type 1 diabetes

Summary Type 1 diabetes (T1D) is a common organ‐specific autoimmune disease of complex aetiology, involving the interaction of a large number of disease‐associated genes. By comparison of a Danish population sample of 253 Caucasian children and adolescents with T1D and a control group consisted of 3...

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Veröffentlicht in:International Journal of Immunogenetics 2007-12, Vol.34 (6), p.469-473
Hauptverfasser: Nielsen, C., Hansen, D., Husby, S., Lillevang, S. T.
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Sprache:eng
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Zusammenfassung:Summary Type 1 diabetes (T1D) is a common organ‐specific autoimmune disease of complex aetiology, involving the interaction of a large number of disease‐associated genes. By comparison of a Danish population sample of 253 Caucasian children and adolescents with T1D and a control group consisted of 354 unrelated healthy blood donors, the present study provides evidence of an isolated association of the disease‐associated PTPN22 1858T‐allele with T1D to the female sex. Furthermore, the present data suggest that PTPN22 genotypes affect the age of onset in a sex‐specific manner. The increased frequency of the risk allele and its association with age at onset in female T1D children and adolescents indicates that the genetic contribution to disease pathogenesis is more prominent in females in this population of Danish patients.
ISSN:1744-3121
1744-313X
1365-2370
DOI:10.1111/j.1744-313X.2007.00720.x