Specificity of relapses and metastases of experimental transplanted Ehrlich carcinoma and B16 melanoma

Experiments on female (CBAxC57Bl/6)F1 mice with simultaneously transplanted Ehrlich carcinoma and B16 melanoma showed that removal of one of the primary nodes led to metastasizing of the removed tumor alone. It seems that this specificity of the inhibitory effect of the primary tumor can be explaine...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2007-01, Vol.143 (1), p.80-82
Hauptverfasser:	Sitdikova, S M, Amandzholov, B S, Kiselevskii, M V, Donenko, F V
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carcinoma, Ehrlich Tumor - mortality Carcinoma, Ehrlich Tumor - secondary Carcinoma, Ehrlich Tumor - surgery Female Melanoma, Experimental - mortality Melanoma, Experimental - secondary Melanoma, Experimental - surgery Mice Mice, Inbred C57BL Mice, Inbred CBA Neoplasm Recurrence, Local Neoplasm Transplantation
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Beschreibung
Zusammenfassung:	Experiments on female (CBAxC57Bl/6)F1 mice with simultaneously transplanted Ehrlich carcinoma and B16 melanoma showed that removal of one of the primary nodes led to metastasizing of the removed tumor alone. It seems that this specificity of the inhibitory effect of the primary tumor can be explained by peculiarities of glycosylation and subsequent complex formation of serum proteins with the tumor.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-007-0022-1