Aging of human skeletal muscles

Normal aging in humans is associated with progressive decrease in skeletal muscle mass and strength (sarcopenia) which contributes to frailty and falls. The age associated changes in body composition result from lower levels of anabolic hormones, oxidative damage, neuromuscular alterations and a gen...

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Veröffentlicht in:	Collegium antropologicum 2005-06, Vol.29 (1), p.67-70
Hauptverfasser:	Nikolić, Marina, Bajek, Snjezana, Bobinac, Dragica, Vranić, Tamara Soić, Jerković, Romana
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aging - physiology Cytokines - physiology Frail Elderly Growth Substances - physiology Humans Life Style Middle Aged Motor Neurons Muscle Weakness Muscle, Skeletal - anatomy & histology Muscle, Skeletal - growth & development Muscle, Skeletal - metabolism Muscular Atrophy Oxidative Stress Protein Biosynthesis
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Beschreibung
Zusammenfassung:	Normal aging in humans is associated with progressive decrease in skeletal muscle mass and strength (sarcopenia) which contributes to frailty and falls. The age associated changes in body composition result from lower levels of anabolic hormones, oxidative damage, neuromuscular alterations and a general decrease in muscle protein turnover. In this review we discuss the potential mechanisms and physical activity as prevention and treatment of sarcopenia.
ISSN:	0350-6134