SNARE complexes prepare for membrane fusion

According to a popular theory, the three presynaptic SNARE proteins (syntaxin 1, synaptobrevin 2 and SNAP-25) drive neuroexocytosis by forming a complex that forces vesicle and plasma membranes together. However, individual reactions in this process have been difficult to resolve. Now, two groups ha...

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Veröffentlicht in:	Trends in neurosciences (Regular ed.) 2005-09, Vol.28 (9), p.453-455
1. Verfasser:	Sorensen, Jakob B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell physiology Exocytosis - physiology Fundamental and applied biological sciences. Psychology General aspects. Models. Methods Humans Membrane Fusion - physiology Membranes Molecular and cellular biology Neurology Neurons - metabolism Neurotransmission Proteins SNARE Proteins Synaptic Membranes - metabolism Synaptic Vesicles - metabolism Syntaxin 1 Vertebrates: nervous system and sense organs Vesicular Transport Proteins - metabolism
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Beschreibung
Zusammenfassung:	According to a popular theory, the three presynaptic SNARE proteins (syntaxin 1, synaptobrevin 2 and SNAP-25) drive neuroexocytosis by forming a complex that forces vesicle and plasma membranes together. However, individual reactions in this process have been difficult to resolve. Now, two groups have succeeded in studying a very early and a very late step in the fusion process.
ISSN:	0166-2236 1878-108X
DOI:	10.1016/j.tins.2005.06.007