Gender influence on postprandial lipemia in heterozygotes for familial hypercholesterolemia

The aim of this study was to evaluate the influence of gender differences on triglyceride (TG) response after a fatty meal in clinically defined heterozygous (h) patients with familial hypercholesterolemia (FH). Nineteen hFH men were age-matched with an equal number of premenopausal women. Plasma TG...

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Veröffentlicht in:	Annals of clinical and laboratory science 2007, Vol.37 (4), p.335-342
Hauptverfasser:	Kolovou, Genovefa D, Anagnostopoulou, Katherine K, Damaskos, Dimitris S, Mihas, Constantinos, Mavrogeni, Sofia, Hatzigeorgiou, George, Theodoridis, Theodor, Mikhailidis, Dimitri P, Cokkinos, Dennis V
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Female Genetic Predisposition to Disease Heterozygote Humans Hypercholesterolemia - diagnosis Hypercholesterolemia - genetics Hypercholesterolemia - physiopathology Hyperlipidemias - blood Hyperlipidemias - diagnosis Hyperlipidemias - genetics Male Middle Aged Postprandial Period Sex Characteristics Triglycerides - blood
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Zusammenfassung:	The aim of this study was to evaluate the influence of gender differences on triglyceride (TG) response after a fatty meal in clinically defined heterozygous (h) patients with familial hypercholesterolemia (FH). Nineteen hFH men were age-matched with an equal number of premenopausal women. Plasma TG was measured before and 2, 4, 6, and 8 hr after a standardized fat load. The men with hFH had a greater body mass index (BMI) than hFH women. An abnormal postprandial response was observed in 63% and 16% of hFH men and women, respectively. The mean TG-area under the curve value was higher in hFH men compared to hFH women. Both gender (p = 0.032) and BMI (p = 0.006) equally affected postprandial TG response, but fasting TG levels (p
ISSN:	0091-7370