Endomorphins interact with tachykinin receptors

Soon after the discovery of endomorphins several studies indicated differences between pharmacological effects of endomorphins and other MOR selective ligands, as well as differences between the effects of endomorphin I and endomorphin II. We now propose that these differences are the result of an a...

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Veröffentlicht in:	Peptides (New York, N.Y. : 1980) N.Y. : 1980), 2005-09, Vol.26 (9), p.1667-1669
Hauptverfasser:	Kosson, Piotr, Bonney, Iwona, Carr, Daniel B., Lipkowski, Andrzej W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding, Competitive Biological and medical sciences Cell Membrane - metabolism CHO Cells Cricetinae Cricetulus Endomorphin Fundamental and applied biological sciences. Psychology Guinea Pigs Humans Ileum - drug effects Ileum - physiology In Vitro Techniques Molecular Structure Neurokinin-1 Receptor Antagonists Oligopeptides - chemistry Oligopeptides - metabolism Peptide Fragments - pharmacology Radioligand Assay Receptors, Neurokinin-1 - genetics Receptors, Neurokinin-1 - metabolism Receptors, Neurokinin-2 - antagonists & inhibitors Receptors, Neurokinin-2 - genetics Receptors, Neurokinin-2 - metabolism Receptors, Neurokinin-3 - genetics Receptors, Neurokinin-3 - metabolism Receptors, Opioid - metabolism Receptors, Tachykinin - antagonists & inhibitors Receptors, Tachykinin - metabolism Substance P - pharmacology Tachykinin antagonist Vertebrates: endocrinology
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Zusammenfassung:	Soon after the discovery of endomorphins several studies indicated differences between pharmacological effects of endomorphins and other MOR selective ligands, as well as differences between the effects of endomorphin I and endomorphin II. We now propose that these differences are the result of an additional non-opioid property of endomorphins, namely, their weak antagonist properties with respect to tachykinin NK 1 and NK 2 receptors.
ISSN:	0196-9781 1873-5169
DOI:	10.1016/j.peptides.2005.02.006