Membrane-Mimetic Nanocarriers Formed by a Dipalmitoylated Cell-Penetrating Peptide

Detergent activity is conferred upon a cell‐penetrating peptide by dipalmitoylation, and the peptide can incorporate large amounts of phospholipid into supramolecular particles with unique physicochemical properties. These nanocarriers combine the advantages of both liposomes and micelles as they of...

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Veröffentlicht in:Angewandte Chemie International Edition 2005-08, Vol.44 (33), p.5252-5255
Hauptverfasser: Keller, Sandro, Sauer, Ines, Strauss, Holger, Gast, Klaus, Dathe, Margitta, Bienert, Michael
Format: Artikel
Sprache:eng
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Zusammenfassung:Detergent activity is conferred upon a cell‐penetrating peptide by dipalmitoylation, and the peptide can incorporate large amounts of phospholipid into supramolecular particles with unique physicochemical properties. These nanocarriers combine the advantages of both liposomes and micelles as they offer a membrane‐like environment in spite of their small size, thus preserving the biofunctionality of the vector peptide and affording efficient internalization into live cells.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200500519