Vascular Invasion is Underrecognized in Colorectal Cancer Using Conventional Hematoxylin and Eosin Staining

PURPOSE: METHODS: RESULTS:Vascular invasion was more commonly identified in Dukes C (pTanyN1/2) (vascular invasion seen in 24 of 25 cases by at least 1 method) than Dukes B tumors (pT3/4N0) (vascular invasion seen in 14 of 25 cases by at least 1 method). Vascular invasion was identified in significa...

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Veröffentlicht in:	Diseases of the colon & rectum 2007-11, Vol.50 (11), p.1867-1872
Hauptverfasser:	Kingston, Elizabeth F, Goulding, Helen, Bateman, Adrian C
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, CD34 - metabolism Biological and medical sciences Colorectal cancer Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Coloring Agents Endothelium, Vascular - pathology Eosine Yellowish-(YS) Fluorescent Dyes Gastroenterology. Liver. Pancreas. Abdomen Hematoxylin Humans Immunohistochemistry Medical sciences Neoplasm Invasiveness Platelet Endothelial Cell Adhesion Molecule-1 - metabolism Prognosis Sensitivity and Specificity Staining and Labeling - methods Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors
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Zusammenfassung:	PURPOSE: METHODS: RESULTS:Vascular invasion was more commonly identified in Dukes C (pTanyN1/2) (vascular invasion seen in 24 of 25 cases by at least 1 method) than Dukes B tumors (pT3/4N0) (vascular invasion seen in 14 of 25 cases by at least 1 method). Vascular invasion was identified in significantly more cases using elastic van gieson (24 cases; P = 0.0001), CD31 (18 cases; P = 0.0064), and CD34 (21 cases; P < 0.0001) than with hematoxylin and eosin alone (5 cases). CONCLUSIONS:
ISSN:	0012-3706 1530-0358
DOI:	10.1007/s10350-007-9021-6