Determination of solifenacin succinate, a novel muscarinic receptor antagonist, and its major metabolite in rat plasma by semi-micro high performance liquid chromatography
A sensitive and specific method for the simultaneous determination of the unchanged drug (solifenacin) and its major metabolite (M1, 4 S-hydroxy solifenacin) in rat plasma was developed and validated. Both solifenacin and M1 were extracted from rat plasma by a two-step liquid–liquid extraction and a...
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| Veröffentlicht in: | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2007-11, Vol.859 (2), p.241-245 |
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| container_title | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences |
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| creator | Yanagihara, Takamitsu Aoki, Toshiko Soeishi, Yoshiaki Iwatsubo, Takafumi Kamimura, Hidetaka |
| description | A sensitive and specific method for the simultaneous determination of the unchanged drug (solifenacin) and its major metabolite (M1, 4
S-hydroxy solifenacin) in rat plasma was developed and validated. Both solifenacin and M1 were extracted from rat plasma by a two-step liquid–liquid extraction and analyzed by semi-micro HPLC with UV detection at an absorbance wavelength of 220
nm. The chromatographic separations were performed on a TSKgel ODS-80Ts (5
μm, 150
mm
×
2.0
mm i.d.) reversed-phase column with a mobile phase of 0.1
M phosphate buffer (pH 3.0):acetonitrile (71:29, v/v). The intra-day precision (expressed as coefficient of variation, CV) ranged from 0.4% to 1.7%, and the accuracy (expressed as relative error, RE) ranged from −5.2% to 2.0% for solifenacin. The corresponding precision ranged from 1.3% to 3.2%, and accuracy ranged from −4.0% to 8.6% for M1. The lower limit of quantitation for both solifenacin and M1 was 2
ng/ml when 1
ml of plasma was used. No endogenous interference was observed in rat plasma. |
| doi_str_mv | 10.1016/j.jchromb.2007.10.005 |
| format | Article |
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S-hydroxy solifenacin) in rat plasma was developed and validated. Both solifenacin and M1 were extracted from rat plasma by a two-step liquid–liquid extraction and analyzed by semi-micro HPLC with UV detection at an absorbance wavelength of 220
nm. The chromatographic separations were performed on a TSKgel ODS-80Ts (5
μm, 150
mm
×
2.0
mm i.d.) reversed-phase column with a mobile phase of 0.1
M phosphate buffer (pH 3.0):acetonitrile (71:29, v/v). The intra-day precision (expressed as coefficient of variation, CV) ranged from 0.4% to 1.7%, and the accuracy (expressed as relative error, RE) ranged from −5.2% to 2.0% for solifenacin. The corresponding precision ranged from 1.3% to 3.2%, and accuracy ranged from −4.0% to 8.6% for M1. The lower limit of quantitation for both solifenacin and M1 was 2
ng/ml when 1
ml of plasma was used. No endogenous interference was observed in rat plasma.</description><identifier>ISSN: 1570-0232</identifier><identifier>EISSN: 1873-376X</identifier><identifier>DOI: 10.1016/j.jchromb.2007.10.005</identifier><identifier>PMID: 17977808</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Analysis ; Analytical, structural and metabolic biochemistry ; Animals ; Biological and medical sciences ; Chromatography, High Pressure Liquid - methods ; Drug Stability ; Fundamental and applied biological sciences. Psychology ; General pharmacology ; HPLC ; Male ; Medical sciences ; Metabolite ; Microchemistry - methods ; Pharmacology. Drug treatments ; Plasma ; Quinuclidines - blood ; Quinuclidines - metabolism ; Rat ; Rats ; Rats, Inbred F344 ; Sensitivity and Specificity ; Solifenacin Succinate ; Solifenacin succinate (YM905) ; Tetrahydroisoquinolines - blood ; Tetrahydroisoquinolines - metabolism ; UV detection</subject><ispartof>Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2007-11, Vol.859 (2), p.241-245</ispartof><rights>2007 Elsevier B.V.</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c488t-d48e7d8fbfbfc4fc34beca0e8f240d1569018e3ba99fd204cec9c9bb6c1d4c0c3</citedby><cites>FETCH-LOGICAL-c488t-d48e7d8fbfbfc4fc34beca0e8f240d1569018e3ba99fd204cec9c9bb6c1d4c0c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jchromb.2007.10.005$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3538,27906,27907,45977</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19229192$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17977808$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yanagihara, Takamitsu</creatorcontrib><creatorcontrib>Aoki, Toshiko</creatorcontrib><creatorcontrib>Soeishi, Yoshiaki</creatorcontrib><creatorcontrib>Iwatsubo, Takafumi</creatorcontrib><creatorcontrib>Kamimura, Hidetaka</creatorcontrib><title>Determination of solifenacin succinate, a novel muscarinic receptor antagonist, and its major metabolite in rat plasma by semi-micro high performance liquid chromatography</title><title>Journal of chromatography. B, Analytical technologies in the biomedical and life sciences</title><addtitle>J Chromatogr B Analyt Technol Biomed Life Sci</addtitle><description>A sensitive and specific method for the simultaneous determination of the unchanged drug (solifenacin) and its major metabolite (M1, 4
S-hydroxy solifenacin) in rat plasma was developed and validated. Both solifenacin and M1 were extracted from rat plasma by a two-step liquid–liquid extraction and analyzed by semi-micro HPLC with UV detection at an absorbance wavelength of 220
nm. The chromatographic separations were performed on a TSKgel ODS-80Ts (5
μm, 150
mm
×
2.0
mm i.d.) reversed-phase column with a mobile phase of 0.1
M phosphate buffer (pH 3.0):acetonitrile (71:29, v/v). The intra-day precision (expressed as coefficient of variation, CV) ranged from 0.4% to 1.7%, and the accuracy (expressed as relative error, RE) ranged from −5.2% to 2.0% for solifenacin. The corresponding precision ranged from 1.3% to 3.2%, and accuracy ranged from −4.0% to 8.6% for M1. The lower limit of quantitation for both solifenacin and M1 was 2
ng/ml when 1
ml of plasma was used. No endogenous interference was observed in rat plasma.</description><subject>Analysis</subject><subject>Analytical, structural and metabolic biochemistry</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Chromatography, High Pressure Liquid - methods</subject><subject>Drug Stability</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General pharmacology</subject><subject>HPLC</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolite</subject><subject>Microchemistry - methods</subject><subject>Pharmacology. Drug treatments</subject><subject>Plasma</subject><subject>Quinuclidines - blood</subject><subject>Quinuclidines - metabolism</subject><subject>Rat</subject><subject>Rats</subject><subject>Rats, Inbred F344</subject><subject>Sensitivity and Specificity</subject><subject>Solifenacin Succinate</subject><subject>Solifenacin succinate (YM905)</subject><subject>Tetrahydroisoquinolines - blood</subject><subject>Tetrahydroisoquinolines - metabolism</subject><subject>UV detection</subject><issn>1570-0232</issn><issn>1873-376X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcuK3DAQRU1IyDyST0jQJlmNOyW_ZK9CmDxhIJsEsjNyudQtY0keSR7ob8pPRj1tmGUQSKLqVEl1b5a94bDjwJsP027Cg3dm2BUAIsV2APWz7JK3osxL0fx5nu61gByKsrjIrkKYALgAUb7MLrjohGihvcz-fqZI3mgro3aWOcWCm7UiK1FbFlbEU4pumGTWPdDMzBpQem01Mk9IS3SeSRvl3lkdYuLsyHQMzMgpZQxFOaSGkVhq52VkyyyDkWw4skBG50ajd-yg9we2kFfOG2mR2KzvVz2yxwlldHsvl8PxVfZCyTnQ6-28zn5__fLr9nt-9_Pbj9tPdzlWbRvzsWpJjK0a0sJKYVkNhBKoVUUFI6-bDnhL5SC7To0FVEjYYTcMDfKxQsDyOnt_7rt4d79SiL3RAWmepSW3hr5pqw4aqBNYn8E0QwieVL94baQ_9hz6k0v91G8u9SeXTmF4rHu7PbAOhsanqs2WBLzbAJnUnpVPoujwxHVF0aUtcR_PHCU5HjT5PqCmJOCokzmxH53-z1f-AaVluYc</recordid><startdate>20071115</startdate><enddate>20071115</enddate><creator>Yanagihara, Takamitsu</creator><creator>Aoki, Toshiko</creator><creator>Soeishi, Yoshiaki</creator><creator>Iwatsubo, Takafumi</creator><creator>Kamimura, Hidetaka</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20071115</creationdate><title>Determination of solifenacin succinate, a novel muscarinic receptor antagonist, and its major metabolite in rat plasma by semi-micro high performance liquid chromatography</title><author>Yanagihara, Takamitsu ; Aoki, Toshiko ; Soeishi, Yoshiaki ; Iwatsubo, Takafumi ; Kamimura, Hidetaka</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c488t-d48e7d8fbfbfc4fc34beca0e8f240d1569018e3ba99fd204cec9c9bb6c1d4c0c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Analysis</topic><topic>Analytical, structural and metabolic biochemistry</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Chromatography, High Pressure Liquid - methods</topic><topic>Drug Stability</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General pharmacology</topic><topic>HPLC</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolite</topic><topic>Microchemistry - methods</topic><topic>Pharmacology. Drug treatments</topic><topic>Plasma</topic><topic>Quinuclidines - blood</topic><topic>Quinuclidines - metabolism</topic><topic>Rat</topic><topic>Rats</topic><topic>Rats, Inbred F344</topic><topic>Sensitivity and Specificity</topic><topic>Solifenacin Succinate</topic><topic>Solifenacin succinate (YM905)</topic><topic>Tetrahydroisoquinolines - blood</topic><topic>Tetrahydroisoquinolines - metabolism</topic><topic>UV detection</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yanagihara, Takamitsu</creatorcontrib><creatorcontrib>Aoki, Toshiko</creatorcontrib><creatorcontrib>Soeishi, Yoshiaki</creatorcontrib><creatorcontrib>Iwatsubo, Takafumi</creatorcontrib><creatorcontrib>Kamimura, Hidetaka</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of chromatography. B, Analytical technologies in the biomedical and life sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yanagihara, Takamitsu</au><au>Aoki, Toshiko</au><au>Soeishi, Yoshiaki</au><au>Iwatsubo, Takafumi</au><au>Kamimura, Hidetaka</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Determination of solifenacin succinate, a novel muscarinic receptor antagonist, and its major metabolite in rat plasma by semi-micro high performance liquid chromatography</atitle><jtitle>Journal of chromatography. B, Analytical technologies in the biomedical and life sciences</jtitle><addtitle>J Chromatogr B Analyt Technol Biomed Life Sci</addtitle><date>2007-11-15</date><risdate>2007</risdate><volume>859</volume><issue>2</issue><spage>241</spage><epage>245</epage><pages>241-245</pages><issn>1570-0232</issn><eissn>1873-376X</eissn><abstract>A sensitive and specific method for the simultaneous determination of the unchanged drug (solifenacin) and its major metabolite (M1, 4
S-hydroxy solifenacin) in rat plasma was developed and validated. Both solifenacin and M1 were extracted from rat plasma by a two-step liquid–liquid extraction and analyzed by semi-micro HPLC with UV detection at an absorbance wavelength of 220
nm. The chromatographic separations were performed on a TSKgel ODS-80Ts (5
μm, 150
mm
×
2.0
mm i.d.) reversed-phase column with a mobile phase of 0.1
M phosphate buffer (pH 3.0):acetonitrile (71:29, v/v). The intra-day precision (expressed as coefficient of variation, CV) ranged from 0.4% to 1.7%, and the accuracy (expressed as relative error, RE) ranged from −5.2% to 2.0% for solifenacin. The corresponding precision ranged from 1.3% to 3.2%, and accuracy ranged from −4.0% to 8.6% for M1. The lower limit of quantitation for both solifenacin and M1 was 2
ng/ml when 1
ml of plasma was used. No endogenous interference was observed in rat plasma.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>17977808</pmid><doi>10.1016/j.jchromb.2007.10.005</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2007-11, Vol.859 (2), p.241-245 |
| issn | 1570-0232 1873-376X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68490605 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Analysis Analytical, structural and metabolic biochemistry Animals Biological and medical sciences Chromatography, High Pressure Liquid - methods Drug Stability Fundamental and applied biological sciences. Psychology General pharmacology HPLC Male Medical sciences Metabolite Microchemistry - methods Pharmacology. Drug treatments Plasma Quinuclidines - blood Quinuclidines - metabolism Rat Rats Rats, Inbred F344 Sensitivity and Specificity Solifenacin Succinate Solifenacin succinate (YM905) Tetrahydroisoquinolines - blood Tetrahydroisoquinolines - metabolism UV detection |
| title | Determination of solifenacin succinate, a novel muscarinic receptor antagonist, and its major metabolite in rat plasma by semi-micro high performance liquid chromatography |
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