Activity-based fluorescent reporters for monoamine oxidases in living cells

Activity-based fluorescent reporters for monoamine oxidases in living cells

Monoamine Oxidase Reporters 1 and 2 (MR1 and MR2) are substrate-tethered activity probes that utilize a tandem amine oxidation/beta-elimination mechanism to detect MAO chemistry in vitro and in living cells directly and specifically without the need for additional enzymes or other activating reagent...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2007-01 (44), p.4647-4649
Hauptverfasser: Albers, Aaron E, Rawls, Katherine A, Chang, Christopher J
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Enzyme Activation
Fluorescent Dyes - chemical synthesis
Fluorescent Dyes - chemistry
Molecular Structure
Monoamine Oxidase - chemistry
PC12 Cells
Rats
Time Factors
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Beschreibung
Zusammenfassung:Monoamine Oxidase Reporters 1 and 2 (MR1 and MR2) are substrate-tethered activity probes that utilize a tandem amine oxidation/beta-elimination mechanism to detect MAO chemistry in vitro and in living cells directly and specifically without the need for additional enzymes or other activating reagents.
ISSN:1359-7345
1364-548X
DOI:10.1039/b713190a