Alzheimer's disease: the lipid connection

Alzheimer's disease is the most common neurodegenerative disorder. This short review summarizes the current knowledge about the role of lipids, especially cholesterol, sphingolipids, plasmalogens, and polyunsaturated fatty acids in Alzheimer's disease etiology, pathogenesis, risk-factors,...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of neurochemistry 2007-11, Vol.103 (s1), p.159-170
Hauptverfasser:	Hartmann, Tobias, Kuchenbecker, Johannna, Grimm, Marcus O.W
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Alzheimer Disease - metabolism Alzheimers disease amyloid Animals Biochemistry Cholesterol Fatty acids function Humans Lipids Lipids - physiology Models, Biological Neurology Peptides Proteins sphingolipids
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Alzheimer's disease is the most common neurodegenerative disorder. This short review summarizes the current knowledge about the role of lipids, especially cholesterol, sphingolipids, plasmalogens, and polyunsaturated fatty acids in Alzheimer's disease etiology, pathogenesis, risk-factors, prevention, treatment, and the function of the amyloid precursor protein and the amyloid peptides in lipid homeostasis.
ISSN:	0022-3042 1471-4159
DOI:	10.1111/j.1471-4159.2007.04715.x