Differential expression of survivin-2B and survivin-DeltaEx3 is inversely associated with disease relapse and patient survival in non-small-cell lung cancer (NSCLC)

Although it was observed that inhibition of the antiapoptotic protein survivin expression in lung cancer cells induces apoptosis, the expression and role of survivin variants (survivin-2B and survivin-DeltaEx3) in lung cancer have not yet been characterized. We analyzed 24 non-small-cell lung cancer...

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Veröffentlicht in:	Lung cancer (Amsterdam, Netherlands) Netherlands), 2005-09, Vol.49 (3), p.353-361
Hauptverfasser:	Ling, Xiang, Yang, Jie, Tan, Dongfeng, Ramnath, Nithya, Younis, Tallal, Bundy, Brian N, Slocum, Harry K, Yang, Lily, Zhou, Muxiang, Li, Fengzhi
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - mortality Cell Line, Tumor Cell Proliferation Cell Survival Cloning, Molecular DNA Fragmentation DNA Primers - chemistry Flow Cytometry Gene Expression Regulation, Neoplastic Genetic Vectors Humans Inhibitor of Apoptosis Proteins Lung Neoplasms - metabolism Lung Neoplasms - mortality Membrane Potentials Microscopy, Fluorescence Microtubule-Associated Proteins - biosynthesis Mitochondria - metabolism Neoplasm Proteins - biosynthesis Neoplasms - metabolism Polymerase Chain Reaction Propidium - pharmacology Recurrence Reverse Transcriptase Polymerase Chain Reaction RNA - metabolism Time Factors Treatment Outcome Tumor Cells, Cultured
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Zusammenfassung:	Although it was observed that inhibition of the antiapoptotic protein survivin expression in lung cancer cells induces apoptosis, the expression and role of survivin variants (survivin-2B and survivin-DeltaEx3) in lung cancer have not yet been characterized. We analyzed 24 non-small-cell lung cancer (NSCLC) samples by semi-quantitative RT-PCR. Surprisingly, our results revealed that high-level expression of survivin-2B is significantly associated with the patient category of "no relapse and alive" (p-value
ISSN:	0169-5002