Jumping translocations in multiple myeloma

Jumping translocations (JT) have been defined as nonreciprocal translocations involving a same donor chromosome arm or chromosome segment onto two or more recipient chromosomes in different cell lines in the same patient, leading to a mosaic karyotype. This definition has been expanded to also inclu...

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Veröffentlicht in:Cancer genetics and cytogenetics 2005-09, Vol.161 (2), p.159-163
Hauptverfasser: Jamet, Déborah, Marzin, Youna, Douet-Guilbert, Nathalie, Morel, Frédéric, Le Bris, Marie-Josée, Herry, Angèle, Banzakour, Said, Bourquard, Pascal, Morice, Patrick, Abgrall, Jean François, Berthou, Christian, De Braekeleer, Marc
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Sprache:eng
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Zusammenfassung:Jumping translocations (JT) have been defined as nonreciprocal translocations involving a same donor chromosome arm or chromosome segment onto two or more recipient chromosomes in different cell lines in the same patient, leading to a mosaic karyotype. This definition has been expanded to also include extra copies of a same donor segment on different recipient chromosomes in a single clone. Six patients with multiple myeloma and JT involving chromosome arm 1q were identified among 37 patients presenting with chromosome 1 abnormalities. All six patients had an advanced disease and a short survival. The literature review allowed us to identify 24 additional patients with JT. Chromosomes 16 and 19 were the recipients in 11 (45.8%) and 6 (25%) of these 24 patients, respectively. Breakpoints on the recipient chromosomes were pericentromeric in 46.2% and telomeric in 40.4% of the breakpoints recorded. Since telomeres are made of (TTAGGG)n tandem DNA repeats that are also found in the pericentromeric heterochromatic regions (interstital telomeric sequences), it is presumed that jumping translocations arise through illegimate recombination between telomere repeat sequences and interstitial telomeric sequences.
ISSN:0165-4608
1873-4456
DOI:10.1016/j.cancergencyto.2005.01.017