Stimuli‐Responsive Controlled Drug Release from a Hollow Mesoporous Silica Sphere/Polyelectrolyte Multilayer Core–Shell Structure

Stimuli‐Responsive Controlled Drug Release from a Hollow Mesoporous Silica Sphere/Polyelectrolyte Multilayer Core–Shell Structure

Keeping drugs under control: Hydrothermally stable, hollow mesoporous silica spheres have a high drug storage capacity, and polyelectrolyte multilayers coated on the spheres act as a switch for drug release which is controlled by the pH or ionic strength of the release medium. The picture shows the...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Angewandte Chemie International Edition 2005-08, Vol.44 (32), p.5083-5087
Hauptverfasser: Zhu, Yufang, Shi, Jianlin, Shen, Weihua, Dong, Xiaoping, Feng, Jingwei, Ruan, Meilin, Li, Yongsheng
Format: Artikel
Sprache:eng
Schlagworte:
Delayed-Action Preparations
drug delivery
Electrolytes - chemistry
Ibuprofen - chemistry
mesoporous materials
multilayers
nanostructures
Nanostructures - chemistry
Polyamines - chemistry
polyelectrolytes
Porosity
Silicon Dioxide - chemistry
Solubility
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Keeping drugs under control: Hydrothermally stable, hollow mesoporous silica spheres have a high drug storage capacity, and polyelectrolyte multilayers coated on the spheres act as a switch for drug release which is controlled by the pH or ionic strength of the release medium. The picture shows the release of ibuprofen (IBU) from spheres with and without coatings of sodium polystyrene sulfonate (PSS) and poly(allylamine hydrochloride) (PAH).
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200501500