Statics and dynamics of single dna molecules confined in nanochannels

The successful design of nanofluidic devices for the manipulation of biopolymers requires an understanding of how the predictions of soft condensed matter physics scale with device dimensions. Here we present measurements of DNA extended in nanochannels and show that below a critical width roughly t...

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Veröffentlicht in:	Physical review letters 2005-05, Vol.94 (19), p.196101.1-196101.4, Article 196101
Hauptverfasser:	REISNER, Walter, MORTON, Keith J, RIEHN, Robert, YAN MEI WANG, ZHAONING YU, ROSEN, Michael, STURM, James C, CHOU, Stephen Y, FREY, Erwin, AUSTIN, Robert H
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Bacteriophage lambda - chemistry Bacteriophage lambda - genetics Biological and medical sciences Dna, deoxyribonucleoproteins DNA, Viral - chemistry DNA, Viral - immunology Fundamental and applied biological sciences. Psychology Nanotechnology - methods Nanotubes - chemistry Nucleic acids Silicon Dioxide - chemistry
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Beschreibung
Zusammenfassung:	The successful design of nanofluidic devices for the manipulation of biopolymers requires an understanding of how the predictions of soft condensed matter physics scale with device dimensions. Here we present measurements of DNA extended in nanochannels and show that below a critical width roughly twice the persistence length there is a crossover in the polymer physics.
ISSN:	0031-9007 1079-7114
DOI:	10.1103/physrevlett.94.196101