RISK FACTORS FOR MORTALITY IN CHILDREN WITH CANDIDEMIA

RISK FACTORS FOR MORTALITY IN CHILDREN WITH CANDIDEMIA

We performed a retrospective cohort study of hospitalized children with positive blood cultures for Candida species. Independent risk factors for mortality by multivariable analysis were location in the pediatric intensive care unit at the time of infection (hazard ratio, 6.3; 95% confidence interva...

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Veröffentlicht in:The Pediatric infectious disease journal 2005-08, Vol.24 (8), p.736-739
Hauptverfasser: Zaoutis, Theoklis E, Coffin, Susan E, Chu, Jaclyn H, Heydon, Kateri, Zhao, Huaqing, Greves, H Mollie, Walsh, Thomas J
Format: Artikel
Sprache:eng
Schlagworte:
Antifungal Agents - therapeutic use
Biological and medical sciences
Candidiasis - drug therapy
Candidiasis - mortality
Child
Cohort Studies
Female
Fungemia - drug therapy
Fungemia - mortality
Human mycoses
Humans
Infectious diseases
Male
Medical sciences
Mycoses
Mycotic sepsis
Retrospective Studies
Risk Factors
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Zusammenfassung:We performed a retrospective cohort study of hospitalized children with positive blood cultures for Candida species. Independent risk factors for mortality by multivariable analysis were location in the pediatric intensive care unit at the time of infection (hazard ratio, 6.3; 95% confidence interval, 1.6–24.3) and the presence of an arterial catheter (hazard ratio, 2.4; 95% confidence interval, 1.1–5.8). Our findings help identify a group of pediatric patients that should be targeted for future interventions to prevent and treat candidemia.
ISSN:0891-3668
1532-0987
DOI:10.1097/01.inf.0000172938.76561.8e