The Thermal Unfolding of Native Cytochrome c in the Transition from Solution to Gas Phase Probed by Native Electron Capture Dissociation

The Thermal Unfolding of Native Cytochrome c in the Transition from Solution to Gas Phase Probed by Native Electron Capture Dissociation

Unfolding upon dehydration:. What happens to the structure of a native protein that is suddenly exposed to vacuum? Native electron capture dissociation shows that dehydration turns the strongest intramolecular interactions in solution into the weakest in the gas phase.

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Veröffentlicht in:Angewandte Chemie International Edition 2005-08, Vol.44 (31), p.4911-4914
Hauptverfasser: Breuker, Kathrin, McLafferty, Fred W.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Cattle
Cytochromes c - chemistry
Electrons
Gases - chemistry
Heart
hydration
mass spectrometry
native electron capture dissociation
noncovalent interactions
Protein Folding
Protein Structure, Tertiary
protein structures
Sensitivity and Specificity
Solutions - chemistry
Spectrometry, Mass, Electrospray Ionization - methods
Temperature
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Zusammenfassung:Unfolding upon dehydration:. What happens to the structure of a native protein that is suddenly exposed to vacuum? Native electron capture dissociation shows that dehydration turns the strongest intramolecular interactions in solution into the weakest in the gas phase.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200500668