Sildenafil reduces bother associated with erectile dysfunction: pooled analysis of five randomized, double-blind trials

Improvement in bother associated with erectile dysfunction (ED) is an important aspect of successful treatment of ED. Changes in erectile function and the bother associated with ED were assessed in this analysis of pooled data from five 12-week, multicenter, randomized, double-blind, placebo-control...

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Veröffentlicht in:	International journal of impotence research 2007-11, Vol.19 (6), p.584-590
Hauptverfasser:	Seftel, A D, Creanga, D L, Levinson, I P
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Biological and medical sciences Complications and side effects Depression, Mental Dosage and administration Dose-Response Relationship, Drug Double-Blind Method Double-blind studies Drug therapy Erectile dysfunction Erectile Dysfunction - drug therapy Erectile Dysfunction - physiopathology Gynecology. Andrology. Obstetrics Humans Impotence Male Male genital diseases Medical sciences Medicine Medicine & Public Health Middle Aged Non tumoral diseases original-article Penile Erection - drug effects Piperazines - therapeutic use Prevention Prognosis Purines - therapeutic use Reproductive Medicine rology Sildenafil Sildenafil Citrate Sulfones - therapeutic use Urology
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Zusammenfassung:	Improvement in bother associated with erectile dysfunction (ED) is an important aspect of successful treatment of ED. Changes in erectile function and the bother associated with ED were assessed in this analysis of pooled data from five 12-week, multicenter, randomized, double-blind, placebo-controlled, flexible-dose studies of sildenafil. Men who received sildenafil ( n =578, vs placebo, n =550) had significantly greater (least squares mean±s.e.) improvement in erectile function (EF) domain scores of the international index of erectile function (IIEF) (10.0±0.3 vs 1.0±0.3, P
ISSN:	0955-9930 1476-5489
DOI:	10.1038/sj.ijir.3901579