SUMO Teams up with Ubiquitin to Manage Hypoxia

Hypoxia, a condition of severe oxygen shortage, induces a transcriptional response that is important for both normal embryonic development and the growth of tumors. In this issue, Cheng et al. (2007) describe how the stability of the major transcriptional regulator of the hypoxic response, HIF1α, is...

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Veröffentlicht in:	Cell 2007-11, Vol.131 (3), p.446-447
1. Verfasser:	Ulrich, Helle D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Hypoxia Endopeptidases - deficiency Endopeptidases - metabolism Erythropoietin - biosynthesis Erythropoietin - genetics Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Mice Protein Binding Ubiquitin - metabolism Von Hippel-Lindau Tumor Suppressor Protein - metabolism
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Beschreibung
Zusammenfassung:	Hypoxia, a condition of severe oxygen shortage, induces a transcriptional response that is important for both normal embryonic development and the growth of tumors. In this issue, Cheng et al. (2007) describe how the stability of the major transcriptional regulator of the hypoxic response, HIF1α, is modulated by the interplay between the ubiquitin and the SUMO conjugation systems.
ISSN:	0092-8674 1097-4172
DOI:	10.1016/j.cell.2007.10.026