Frontotemporal dementia with ubiquitinated neuronal inclusions and visuospatial impairment

Dementia with ubiquitinated neuronal inclusions has been described only with frontotemporal dementia (FTD). The authors report a patient with progressive FTD accompanied by prominent impairments in visuospatial cognitive functions. Pathology was characterized by ubiquitin-positive intranuclear and c...

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Veröffentlicht in:	Neurology 2005-08, Vol.65 (3), p.478-480
Hauptverfasser:	MEINER, Z, NEWMAN, J. P, ROSENMAN, H, SOFFER, D, STEINER, I
Format:	Artikel
Sprache:	eng
Schlagworte:	Agnosia - etiology Agnosia - pathology Agnosia - physiopathology Atrophy - etiology Atrophy - pathology Atrophy - physiopathology Biological and medical sciences Cerebral Cortex - pathology Cerebral Cortex - physiopathology Cognition Disorders - etiology Cognition Disorders - pathology Cognition Disorders - physiopathology Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dementia - metabolism Dementia - pathology Dementia - physiopathology Disease Progression Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes Fatal Outcome Humans Inclusion Bodies - pathology Male Medical sciences Memory Disorders - etiology Memory Disorders - pathology Memory Disorders - physiopathology Middle Aged Nervous system (semeiology, syndromes) Neurology Neurons - metabolism Neurons - pathology Psychomotor Performance - physiology Ubiquitin - metabolism
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Zusammenfassung:	Dementia with ubiquitinated neuronal inclusions has been described only with frontotemporal dementia (FTD). The authors report a patient with progressive FTD accompanied by prominent impairments in visuospatial cognitive functions. Pathology was characterized by ubiquitin-positive intranuclear and cytoplasmic neuronal inclusions. Cortical pathology was widespread and posteriorly accentuated but spared the hippocampal dentate gyrus.
ISSN:	0028-3878 1526-632X
DOI:	10.1212/01.wnl.0000171347.28558.56