The relationship between age and carotid artery intima-media thickness, hemoglobin A1c in nondiabetic, healthy geriatric population

The aim of the study was to investigate a casual relationship between age and carotid artery intima-media thickness (IMT) and hemoglobin A1c (HbA1c) levels and to assess the effects of possible risk factors in healthy nondiabetic elderly. Seventy-two healthy, well-educated, nondiabetic, healthy elderlies (mean age: 71.5 ± 5.01 years; 43 male, 29 female) were enrolled in the study. Comprehensive assessments including a battery of psychosocial and functional performance tests were performed to all subjects. All of them were also asked about health prevention topics including exercise, dietary habits, smoking, vaccination, cholesterol screening, etc. Carotid artery IMT was measured by ultrasound. Blood samples were obtained for fasting glucose, HbA1c, cholesterol, triglyceride and fibrinogen. The mean carotid artery IMT was 0.94 ± 0.13 mm and the mean HbA1c level was 5.29 ± 0.65 mg/dl. There was no significant correlation between age and carotid artery IMT ( r s = 0.15), HbA1c levels ( r s = −0.08) and other possible atherosclerosis risk factors. Also there was no correlation between carotid artery IMT and HbA1c levels ( r s = 0.14). Our data indicated that the carotid artery IMT, HbA1c and age are not associated in a geriatric healthy, well-educated population. Comparative studies done on the elderly who do not benefit from preventive health care programs are needed to establish if preventive health care measures and risk factor modification are important in the elderly age group.