FoldIndex©: a simple tool to predict whether a given protein sequence is intrinsically unfolded

FoldIndex©: a simple tool to predict whether a given protein sequence is intrinsically unfolded

An easy-to-use, versatile and freely available graphic web server, FoldIndex© is described: it predicts if a given protein sequence is intrinsically unfolded implementing the algorithm of Uversky and co-workers, which is based on the average residue hydrophobicity and net charge of the sequence. Fol...

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Veröffentlicht in:Bioinformatics 2005-08, Vol.21 (16), p.3435-3438
Hauptverfasser: Prilusky, Jaime, Felder, Clifford E., Zeev-Ben-Mordehai, Tzviya, Rydberg, Edwin H., Man, Orna, Beckmann, Jacques S., Silman, Israel, Sussman, Joel L.
Format: Artikel
Sprache:eng
Schlagworte:
Algorithms
Biological and medical sciences
Computer Graphics
Computer Simulation
Energy Transfer
Fundamental and applied biological sciences. Psychology
General aspects
Internet
Mathematics in biology. Statistical analysis. Models. Metrology. Data processing in biology (general aspects)
Models, Chemical
Models, Molecular
Protein Conformation
Protein Folding
Proteins - analysis
Proteins - chemistry
Sequence Alignment - methods
Sequence Analysis, Protein - methods
Software
Structure-Activity Relationship
User-Computer Interface
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Beschreibung
Zusammenfassung:An easy-to-use, versatile and freely available graphic web server, FoldIndex© is described: it predicts if a given protein sequence is intrinsically unfolded implementing the algorithm of Uversky and co-workers, which is based on the average residue hydrophobicity and net charge of the sequence. FoldIndex© has an error rate comparable to that of more sophisticated fold prediction methods. Sliding windows permit identification of large regions within a protein that possess folding propensities different from those of the whole protein. Availability: FoldIndex© can be accessed at http://bioportal.weizmann.ac.il/fldbin/findex Contact: Joel.Sussman@weizmann.ac.il Supplementary information: http://www.weizmann.ac.il/sb/faculty_pages/Sussman/papers/suppl/Prilusky_2005
ISSN:1367-4803
1460-2059
1367-4811
DOI:10.1093/bioinformatics/bti537