Associations with myocardial infarction of six polymorphisms selected from a three-stage genome-wide association study

Background Coronary heart disease, including its clinical manifestation, myocardial infarction (MI), is a common, complex disease with a substantive genetic component. State-of-the-art genetic epidemiology evaluates thousands of single nucleotide polymorphisms (SNPs) in association with disease case...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The American heart journal 2007-11, Vol.154 (5), p.969-975
Hauptverfasser:	Horne, Benjamin D., PhD, MPH, Carlquist, John F., PhD, Muhlestein, Joseph B., MD, Nicholas, Zachary P., BS, Anderson, Jeffrey L., MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Aged Biological and medical sciences Cardiac Catheterization Cardiology. Vascular system Cardiovascular Cardiovascular disease Coronary Angiography Coronary heart disease Diabetes DNA - genetics Electrocardiography Ethnicity Female Follow-Up Studies Genes Genetic Predisposition to Disease Genome Genome, Human - genetics Genomes Genotype Genotype & phenotype Heart Heart attacks Hospitalization Humans Hypertension Intubation Kinases Linkage Disequilibrium Male Medical imaging Medical sciences Mens health Middle Aged Myocardial Infarction - diagnosis Myocardial Infarction - epidemiology Myocardial Infarction - genetics Myocarditis. Cardiomyopathies Polymorphism, Genetic Prevalence Risk factors Scanners Studies Women
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Background Coronary heart disease, including its clinical manifestation, myocardial infarction (MI), is a common, complex disease with a substantive genetic component. State-of-the-art genetic epidemiology evaluates thousands of single nucleotide polymorphisms (SNPs) in association with disease cases and controls. In an independent but demographically similar population, this study tested 6 SNPs that were previously reported to be associated with MI. Methods Patients hospitalized for an acute MI (n = 413) at an early age (men
ISSN:	0002-8703 1097-6744
DOI:	10.1016/j.ahj.2007.06.032