How Rapidly Do Epoxides Nonspecifically Form Covalent Bonds with Thiols in Water

How Rapidly Do Epoxides Nonspecifically Form Covalent Bonds with Thiols in Water

Rating reaction rates. Due to some concerns about the reactivity of epoxides towards the most abundant and powerful nucleophiles, thiols, in a biological setting, we report kinetic data for the consumption of five common epoxide motifs in the presence of a thiol under biologically relevant condition...

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Veröffentlicht in:Chembiochem : a European journal of chemical biology 2007-11, Vol.8 (16), p.1912-1915
Hauptverfasser: Albert, Brian J, Koide, Kazunori
Format: Artikel
Sprache:eng
Schlagworte:
Biological Factors - chemistry
epoxides
Epoxy Compounds - chemistry
Hydrogen-Ion Concentration
Kinetics
Molecular Structure
natural products
pH dependence
Pyrans - chemistry
Serum Albumin, Bovine - chemistry
Spiro Compounds - chemistry
Sulfhydryl Compounds - chemistry
thiols
Time Factors
Water - chemistry
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Beschreibung
Zusammenfassung:Rating reaction rates. Due to some concerns about the reactivity of epoxides towards the most abundant and powerful nucleophiles, thiols, in a biological setting, we report kinetic data for the consumption of five common epoxide motifs in the presence of a thiol under biologically relevant conditions.
ISSN:1439-4227
1439-7633
DOI:10.1002/cbic.200700365