Morphing into cancer: The role of developmental signaling pathways in brain tumor formation

Morphogens play a critical role in most aspects of development, including expansion and patterning of the central nervous system. Activating germline mutations in components of the Hedgehog and Wnt pathways have provided evidence for the important roles morphogens play in the genesis of brain tumors...

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Veröffentlicht in:	Journal of neurobiology 2005-09, Vol.64 (4), p.458-475
Hauptverfasser:	Fogarty, Marie P., Kessler, Jessica D., Wechsler‐Reya, Robert J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals BMP Bone Morphogenetic Proteins - physiology Brain - growth & development Brain Neoplasms - physiopathology glioblastoma Hedgehog Hedgehog Proteins Humans Intercellular Signaling Peptides and Proteins - physiology medulloblastoma Signal Transduction - physiology Trans-Activators - physiology Transforming Growth Factor beta - physiology Wnt Wnt Proteins
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Zusammenfassung:	Morphogens play a critical role in most aspects of development, including expansion and patterning of the central nervous system. Activating germline mutations in components of the Hedgehog and Wnt pathways have provided evidence for the important roles morphogens play in the genesis of brain tumors such as cerebellar medulloblastoma. In addition, aberrant expression of transforming growth factor‐β (TGF‐β) superfamily members has been demonstrated to contribute to progression of malignant gliomas. This review summarizes our current knowledge about the roles of morphogens in central nervous system tumorigenesis. © 2005 Wiley Periodicals, Inc. J Neurobiol 64: 458–475, 2005
ISSN:	0022-3034 1097-4695
DOI:	10.1002/neu.20166