Human visceral adipose tissue and the plasminogen activator inhibitor type 1

Objective: The objective of this study was to systematically evaluate the molecular basis of the association between visceral fat mass and plasma plasminogen activator inhibitor-1 (PAI-1) levels in man. Design: A comprehensive approach comprising observational, in vitro , and human intervention stud...

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Veröffentlicht in:	International Journal of Obesity 2007-11, Vol.31 (11), p.1671-1679
Hauptverfasser:	Lindeman, J.H.N, Pijl, H, Toet, K, Eilers, P.H.C, Ramshorst, B. van, Buijs, M.M, Bockel, J.H. van, Kooistra, T
Format:	Artikel
Sprache:	eng
Schlagworte:	Abdomen Adipose tissue Adipose tissues Adiposity - physiology Adult anthropometric measurements Anthropometry Aortic aneurysms Biological and medical sciences Body fat body fat distribution Body mass index cytokines Cytokines - biosynthesis Dosage and administration enzyme inhibition enzyme inhibitors Epidemiology Fatty acids Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology Growth hormones Health Promotion and Disease Prevention Human Growth Hormone - deficiency Humans in vivo studies inflammation Inflammation Mediators - metabolism Internal Medicine Intra-Abdominal Fat - anatomy & histology Intra-Abdominal Fat - metabolism Intra-Abdominal Fat - pathology Lipid Metabolism Management Medical sciences Medicine Medicine & Public Health messenger RNA Metabolic Diseases Metabolism Middle Aged nutritional intervention Obesity Obesity - metabolism Obesity - pathology original-article patients Plasma plasminogen activator Plasminogen Activator Inhibitor 1 - blood Plasminogen Activator Inhibitor 1 - genetics plasminogen activator inhibitor type 1 Properties Public Health RNA, Messenger - genetics Thrombolytic drugs Tissue Culture Techniques Tumor Necrosis Factor-alpha - biosynthesis Tumor necrosis factor-TNF Vascular surgery Vertebrates: anatomy and physiology, studies on body, several organs or systems visceral fat
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Beschreibung
Zusammenfassung:	Objective: The objective of this study was to systematically evaluate the molecular basis of the association between visceral fat mass and plasma plasminogen activator inhibitor-1 (PAI-1) levels in man. Design: A comprehensive approach comprising observational, in vitro , and human intervention studies. Measurements and results: We confirmed an exclusive relationship between visceral fat and plasma PAI-1 levels ( r =0.79, P
ISSN:	0307-0565 1476-5497
DOI:	10.1038/sj.ijo.0803650