Early experience with radiofrequency energy ablation therapy for Barrett's esophagus with and without dysplasia

Radiofrequency (RF) ablation using the HALO360 system combined with proton pump inhibitor (PPI) therapy is a new treatment for Barrett's esophagus (BE). We assessed the safety and effectiveness of this combination therapy at a community‐based, BE referral center. After symptom evaluation, endoscopy and histologic assessment, esophageal motility, pH monitoring on PPI, computed tomography, endoscopic ultrasonography and mucosal resection for nodules, we performed HALO360 ablation followed by twice daily PPI and 3‐monthly surveillance for up to 12 months. If metaplasia or dysplasia were present at follow‐up, the patients received a second ablation. Thirteen patients (12 male) were treated, three with high‐grade dysplasia, four with low‐grade and six with non‐dysplastic intestinal metaplasia. The mean baseline BE length was 6 cm (range 2–12); nine patients had an hiatal hernia and two had a prior fundoplication. Esophageal pH