Comparative expression of human endogenous retrovirus-W genes in multiple sclerosis

Human endogenous retroviruses (HERVs) have been associated with multiple sclerosis (MS) pathogenesis. Several related HERV-W sequences have been implicated in disease occurrence and progression; the MS retrovirus (MSRV) is one such element whose envelope protein has been recently demonstrated to be...

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Veröffentlicht in:AIDS research and human retroviruses 2007-10, Vol.23 (10), p.1251-1256
Hauptverfasser: ANTONY, Joseph M, YU ZHU, IZAD, Maryam, WARREN, Kenneth G, VODJGANI, Mohammed, MALLET, Francois, POWER, Christopher
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Sprache:eng
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Zusammenfassung:Human endogenous retroviruses (HERVs) have been associated with multiple sclerosis (MS) pathogenesis. Several related HERV-W sequences have been implicated in disease occurrence and progression; the MS retrovirus (MSRV) is one such element whose envelope protein has been recently demonstrated to be involved in innate immune pathogenesis. To distinguish MSRV from other HERV-W sequences we analyzed the relative abundance of individual HERV-W env sequences by employing a real-time PCR approach using specific oligonucleotide primers and tissue samples from MS and non-MS patients. Our analyses reveal that ERVWE1 env-encoding DNA and RNA exhibited increased detection (p < 0.05) and expression (p < 0.01) in the brains of MS patients. Similarly, ERVWE1 env transcripts were inducible in glial cells (p < 0.05), while comparable changes in MSRV abundance were not observed. These results indicate that individual HERVs might have distinct roles in MS pathogenesis.
ISSN:0889-2229
1931-8405
DOI:10.1089/aid.2006.0274