ABCG1: How critical for cholesterol transport?

In the current issue of Cell Metabolism, Kennedy et al. (2005) have extended our understanding of the ABCG1 transporter. Their studies demonstrate that, at least in macrophages, ABCG1 is responsible for much of the cholesterol efflux that utilizes mature HDL as an acceptor.

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Bibliographische Detailangaben
Veröffentlicht in:	Cell metabolism 2005-02, Vol.1 (2), p.87-88
1. Verfasser:	Shachter, Neil S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals ATP Binding Cassette Transporter, Sub-Family G, Member 1 ATP-Binding Cassette Transporters - metabolism ATP-Binding Cassette Transporters - physiology Biological Transport Cholesterol - metabolism Heterozygote Homozygote Lipoproteins - metabolism Lipoproteins - physiology Lipoproteins, HDL - metabolism Macrophages - metabolism Mice Mice, Knockout Models, Biological Phenotype RNA, Messenger - metabolism
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Beschreibung
Zusammenfassung:	In the current issue of Cell Metabolism, Kennedy et al. (2005) have extended our understanding of the ABCG1 transporter. Their studies demonstrate that, at least in macrophages, ABCG1 is responsible for much of the cholesterol efflux that utilizes mature HDL as an acceptor.
ISSN:	1550-4131 1932-7420
DOI:	10.1016/j.cmet.2005.01.009