Inhibitory effect of cranberry polyphenol on biofilm formation and cysteine proteases of Porphyromonas gingivalis

Background and Objective: The purpose of this study was to investigate the effects of cranberry polyphenol fraction on biofilm formation and activities of Arg‐gingipain and Lys‐gingipain in Porphyromonas gingivalis. Material and Methods: The polyphenol fraction was prepared by using a glass column...

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Veröffentlicht in:	Journal of periodontal research 2007-12, Vol.42 (6), p.589-592
Hauptverfasser:	Yamanaka, A., Kouchi, T., Kasai, K., Kato, T., Ishihara, K., Okuda, K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesins, Bacterial biofilm Biofilms - drug effects Biological and medical sciences cranberry polyphenol Cysteine Endopeptidases cysteine protease Dentistry Flavonoids - pharmacology Fusobacterium nucleatum Fusobacterium nucleatum - drug effects Medical sciences Otorhinolaryngology. Stomatology Phenols - pharmacology Polyphenols Porphyromonas gingivalis Porphyromonas gingivalis - drug effects Porphyromonas gingivalis - enzymology Protease Inhibitors - pharmacology Vaccinium macrocarpon
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Zusammenfassung:	Background and Objective: The purpose of this study was to investigate the effects of cranberry polyphenol fraction on biofilm formation and activities of Arg‐gingipain and Lys‐gingipain in Porphyromonas gingivalis. Material and Methods: The polyphenol fraction was prepared by using a glass column packed with Amberlite XAD 7HP and 70% aqueous ethanol as an elution solvent. Results: Synergistic biofilm formation by P. gingivalis and Fusobacterium nucleatum was significantly inhibited by the polyphenol fraction at a concentration of 250 µg/mL compared with untreated controls (p
ISSN:	0022-3484 1600-0765
DOI:	10.1111/j.1600-0765.2007.00982.x