Phenotype and coronary outcome in Kawasaki's disease

More recently, using IVIG unresponsiveness as a marker for increased risk for coronary artery aneurysms, T Kobayashi and colleagues identified decreased serum sodium, increased percentage of peripheral blood neutrophils, early treatment with IVIG (on or before day 4), raised aspartate aminotransferase, young age, low platelet count, and high C-reactivc protein as high-risk factors.10 When analysed separately, those treated early (on or before day 4 of fever) had higher risk scores than those treated later, suggesting that those treated early had more striking clinical features (which implies more intense inflammation and severe vasculitis).