Brain dopamine transporter levels in treatment and drug naïve adults with ADHD

Attention deficit hyperactivity disorder (ADHD) is the most frequent psychiatric disorder in children, yet data are sparse on its pathophysiology. Particularly relevant are the dopamine transporters since these are the main targets of stimulant medications used for ADHD treatment. Though some imagin...

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Veröffentlicht in:	NeuroImage (Orlando, Fla.) Fla.), 2007-02, Vol.34 (3), p.1182-1190
Hauptverfasser:	Volkow, Nora D., Wang, Gene-Jack, Newcorn, Jeffrey, Fowler, Joanna S., Telang, Frank, Solanto, Mary V., Logan, Jean, Wong, Christopher, Ma, Yeming, Swanson, James M., Schulz, Kurt, Pradhan, Kith
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Attention Deficit Disorder with Hyperactivity - diagnostic imaging Attention Deficit Disorder with Hyperactivity - drug therapy Attention Deficit Disorder with Hyperactivity - metabolism Attention deficit hyperactivity disorder Autoimmune diseases Brain - diagnostic imaging Brain - drug effects Brain - metabolism Carbon Radioisotopes - pharmacokinetics Caudate Central Nervous System Stimulants - administration & dosage Cocaine Cocaine - pharmacokinetics Dopamine Dopamine Plasma Membrane Transport Proteins - metabolism Ethnicity Female Humans Hyperactivity Hypothalamus Independent study Male Medical imaging Noradrenergic Nucleus accumbens PET Positron-Emission Tomography - methods Radiopharmaceuticals - pharmacokinetics Saliency Stimulants Studies Substance abuse treatment Tissue Distribution - drug effects
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Zusammenfassung:	Attention deficit hyperactivity disorder (ADHD) is the most frequent psychiatric disorder in children, yet data are sparse on its pathophysiology. Particularly relevant are the dopamine transporters since these are the main targets of stimulant medications used for ADHD treatment. Though some imaging studies have shown increases in dopamine transporters in ADHD others have not and their role in the neurobiology of ADHD remains unclear. Here we investigate dopamine transporters in ADHD subjects with control of potentially confounding factors (previous medication and/or drug histories, comorbidity) and their association with clinical symptoms. Positron emission tomography and [11C]cocaine were used to measure dopamine transporters in 20 never medicated adults with ADHD and 25 controls. Dopamine transporters were lower in left caudate (13%, p
ISSN:	1053-8119 1095-9572
DOI:	10.1016/j.neuroimage.2006.10.014