Insulin sensitivity, proinflammatory markers and adiponectin in young males with different subtypes of depressive disorder

Summary Objective This study was designed to evaluate insulin sensitivity, proinflammatory markers and adiponectin concentration in young males with different subtypes of depressive disorder. Methods Nonobese young males with depressive disorder (ages between 18 years and 30 years; body mass index, BMI ≤ 25 kg/m2) were recruited and divided into reactive depression (RD, N = 14), major depression (MD, N = 21) and bipolar depression (BD, N = 15) based on clinical course and symptom changes in Hamilton rating scale for depression (HAM‐D). Fourteen age‐ and BMI‐matched healthy males were enrolled as controls. All of the participants received a 75‐g oral glucose tolerance test (OGTT). Insulin sensitivity and β‐cell function were calculated by minimal model method from the frequently sampled intravenous glucose tolerance test. Plasma C‐reactive protein (CRP), adiponectin, tumour necrosis factor‐α (TNF‐α) and interleukin‐6 (IL‐6) were determined. Results Compared to the controls, insulin sensitivity (SI) were significantly lower in MD and BD (0·78 ± 0·09 min−1/pmol and 0·75 ± 0·09 min−1/pmol vs. 1·09 ± 0·08 × 10−5 min−1/pmol, P